| Title |
The complexities of breast cancer desmoplasia
|
|---|---|
| Published in |
Breast Cancer Research, June 2001
|
| DOI | 10.1186/bcr287 |
| Pubmed ID | |
| Authors |
Rosemary A Walker |
| Abstract |
The stromal, or 'desmoplastic', responses seen histologically in primary breast carcinomas can vary from being predominantly cellular (fibroblasts/myofibroblasts) with little collagen to being a dense acellular tissue. The mechanisms underlying the stromal response are complex; paracrine activation of myofibroblasts by growth factors is important but the contribution of cytokines/chemokines should not be ignored. A recent xenograft study has proposed that platelet-derived growth factor (PDGF) is the initiator of the desmoplastic response, but this has not been confirmed by (limited) analyses in vivo. Further studies are required to elaborate the mechanisms of the desmoplastic response, to determine its role in breast cancer progression and whether it is the same for all carcinomas. |
Mendeley readers
The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| India | 1 | <1% |
| Unknown | 132 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 24% |
| Student > Master | 21 | 16% |
| Researcher | 12 | 9% |
| Student > Bachelor | 12 | 9% |
| Student > Doctoral Student | 7 | 5% |
| Other | 16 | 12% |
| Unknown | 34 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 20% |
| Biochemistry, Genetics and Molecular Biology | 19 | 14% |
| Medicine and Dentistry | 16 | 12% |
| Engineering | 11 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 20 | 15% |
| Unknown | 35 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2020.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Breast Cancer Research
#977
of 2,053 outputs
Outputs of similar age
#14,149
of 41,874 outputs
Outputs of similar age from Breast Cancer Research
#1
of 5 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 41,874 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them