Title |
The Immune Pathogenesis of Scleroderma: Context Is Everything
|
---|---|
Published in |
Current Rheumatology Reports, December 2012
|
DOI | 10.1007/s11926-012-0297-8 |
Pubmed ID | |
Authors |
Matthew B. Greenblatt, Antonios O. Aliprantis |
Abstract |
The fundamental mechanisms that drive the pathogenesis of systemic sclerosis (SSc) remain elusive, despite over 50 years of investigation. Here, we review recent progress in the understanding of the immunopathogenesis of SSc. In particular, we consider interleukin-13 (IL13), and its upstream and downstream pathways, as an example of an immune system-derived mediator involved in fibrotic and vascular pathology. Emerging results linking pattern-recognition receptors and interferon pathways to SSc are also stressed. We discuss genetic data linking the immune system to SSc risk and efforts to apply animal models to subsets of patients recently resolved by gene expression profiling. These developments will help build a context for better understanding of previous observations and design of the next generation of studies that may eventually lead to effective treatment. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 2% |
Unknown | 52 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 17% |
Researcher | 8 | 15% |
Student > Ph. D. Student | 8 | 15% |
Student > Postgraduate | 7 | 13% |
Other | 5 | 9% |
Other | 9 | 17% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 34% |
Biochemistry, Genetics and Molecular Biology | 8 | 15% |
Agricultural and Biological Sciences | 8 | 15% |
Nursing and Health Professions | 3 | 6% |
Immunology and Microbiology | 3 | 6% |
Other | 6 | 11% |
Unknown | 7 | 13% |