| Title |
Immunophenotype of lymphocytic infiltration in medullary carcinoma of the breast
|
|---|---|
| Published in |
Virchows Archiv, November 2004
|
| DOI | 10.1007/s00428-004-1143-9 |
| Pubmed ID | |
| Authors |
Hajime Kuroda, Jun-ichi Tamaru, Goi Sakamoto, Kiyoshi Ohnisi, Shinji Itoyama |
| Abstract |
Medullary carcinoma (MC) of the breast is characterized by large anaplastic cells and infiltration by benign lymphocytes. Patients with this pattern of breast carcinoma are considered to have a better prognosis than those with other histological subtypes. We reviewed cases of primary breast carcinoma that were surgically resected between 1990 and 2004. Of these, 13 cases of medullary carcinoma of the breast with lymphocyte infiltration were reported. Tests for CD3, CD4, CD8, CD20, CD56, TIA-1, and granzyme B were performed on paraffin sections. We found that the MC contained very few NK cells, as assessed by their reactivity with the CD56 antibodies. However, MC had a significantly greater percentage of CD3, CD8, TIA-1, and granzyme B lymphocytes infiltrating the stroma of the tumor. Furthermore, more CD8-positive than CD4-positive T-cell lymphocytes were present within the tumor cell nests in MC, as opposed to the proportion in usual ductal carcinoma. The infiltrating cytotoxic/suppressor T cells in MC represent host resistance against cancer, and the high grading of the T-cell infiltration could explain, in part, a key mechanism controlling the good prognosis for this type of tumor and solve the pathological paradox of MC. |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 3% |
| Unknown | 29 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 20% |
| Researcher | 6 | 20% |
| Student > Bachelor | 4 | 13% |
| Other | 4 | 13% |
| Student > Master | 3 | 10% |
| Other | 4 | 13% |
| Unknown | 3 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 50% |
| Biochemistry, Genetics and Molecular Biology | 4 | 13% |
| Agricultural and Biological Sciences | 3 | 10% |
| Immunology and Microbiology | 3 | 10% |
| Social Sciences | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 3 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2022.
All research outputs
#7,447,868
of 22,769,322 outputs
Outputs from Virchows Archiv
#409
of 1,945 outputs
Outputs of similar age
#35,934
of 139,990 outputs
Outputs of similar age from Virchows Archiv
#2
of 4 outputs
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So far Altmetric has tracked 1,945 research outputs from this source. They receive a mean Attention Score of 4.0. This one has gotten more attention than average, scoring higher than 52% of its peers.
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