| Title |
Cellular pathology of Parkinson’s disease: astrocytes, microglia and inflammation
|
|---|---|
| Published in |
Cell and Tissue Research, August 2004
|
| DOI | 10.1007/s00441-004-0944-0 |
| Pubmed ID | |
| Authors |
Peter Teismann, Jörg B. Schulz |
| Abstract |
Parkinson's disease (PD) is a frequent neurological disorder of the basal ganglia, which is characterized by the progressive loss of dopaminergic neurons mainly in the substantia nigra pars compacta (SNpc). Inflammatory processes have been shown to be associated with the pathogenesis of PD. Activated microglia, as well as to a lesser extent reactive astrocytes, are found in the area associated with cell loss, possibly contributing to the inflammatory process by the release of pro-inflammatory prostaglandins or cytokines. Further deleterious factors released by activated microglia or astrocytes are reactive oxygen species. On the other hand, they may mediate neuroprotective properties by the release of trophic factors or the uptake of glutamate. In this review, we will discuss the different aspects of activated glial cells and potential mechanisms that mediate or protect against cell loss in PD. |
Mendeley readers
The data shown below were compiled from readership statistics for 198 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| South Africa | 1 | <1% |
| China | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 190 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 49 | 25% |
| Student > Master | 29 | 15% |
| Researcher | 27 | 14% |
| Student > Bachelor | 23 | 12% |
| Student > Doctoral Student | 10 | 5% |
| Other | 26 | 13% |
| Unknown | 34 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 68 | 34% |
| Neuroscience | 31 | 16% |
| Biochemistry, Genetics and Molecular Biology | 19 | 10% |
| Medicine and Dentistry | 15 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
| Other | 20 | 10% |
| Unknown | 39 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2012.
All research outputs
#5,700,702
of 23,839,820 outputs
Outputs from Cell and Tissue Research
#240
of 2,279 outputs
Outputs of similar age
#10,115
of 59,641 outputs
Outputs of similar age from Cell and Tissue Research
#5
of 15 outputs
Altmetric has tracked 23,839,820 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,279 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 59,641 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.