| Title |
Interaction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1
|
|---|---|
| Published in |
neurogenetics, January 2009
|
| DOI | 10.1007/s10048-009-0172-6 |
| Pubmed ID | |
| Authors |
Michael C. Hanna, Craig Blackstone |
| Abstract |
Mast syndrome (SPG21) is an autosomal-recessive complicated form of hereditary spastic paraplegia characterized by dementia, thin corpus callosum, white matter abnormalities, and cerebellar and extrapyramidal signs in addition to spastic paraparesis. A nucleotide insertion resulting in premature truncation of the SPG21 gene product acidic cluster protein 33 (ACP33)/maspardin underlies this disorder, likely causing loss of protein function. However, little is known about the function of maspardin. Here, we report that maspardin localizes prominently to cytoplasm as well as to membranes, possibly at trans-Golgi network/late endosomal compartments. Immunoprecipitation of maspardin with identification of coprecipitating proteins by mass spectrometry revealed the aldehyde dehydrogenase ALDH16A1 as an interacting protein. This interaction was confirmed using overexpressed proteins as well as by fusion protein pull down experiments, and these proteins colocalized in cells. Further studies of the function of ALDH16A1 and the role of the maspardin-ALDH16A1 interaction in neuronal cells may clarify the cellular pathogenesis of Mast syndrome. |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Norway | 1 | 3% |
| Unknown | 34 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 36% |
| Student > Master | 7 | 19% |
| Student > Ph. D. Student | 5 | 14% |
| Student > Postgraduate | 2 | 6% |
| Student > Bachelor | 1 | 3% |
| Other | 5 | 14% |
| Unknown | 3 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 11 | 31% |
| Agricultural and Biological Sciences | 11 | 31% |
| Medicine and Dentistry | 8 | 22% |
| Psychology | 1 | 3% |
| Social Sciences | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 3 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2017.
All research outputs
#7,454,427
of 22,789,566 outputs
Outputs from neurogenetics
#116
of 376 outputs
Outputs of similar age
#49,642
of 170,471 outputs
Outputs of similar age from neurogenetics
#4
of 8 outputs
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