| Title |
The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, September 2011
|
| DOI | 10.1007/s00406-011-0235-1 |
| Pubmed ID | |
| Authors |
Rainald Mössner, Anna Schuhmacher, Michael Wagner, Leonhard Lennertz, Anja Steinbrecher, Boris B. Quednow, Dan Rujescu, Marcella Rietschel, Wolfgang Maier |
| Abstract |
Genetic factors determining the response to antipsychotic treatment in schizophrenia are poorly understood. A new schizophrenia susceptibility gene, the zinc-finger gene ZNF804A, has recently been identified. To assess the pharmacogenetic importance of this gene, we treated 144 schizophrenia patients and assessed the response of positive and negative symptoms by PANSS. Patients homozygous for the ZNF804A risk allele for schizophrenia (rs1344706 AA) showed poorer improvement of positive symptoms (7.35 ± 0.46) compared to patients with a protective allele (9.41 ± 0.71, P = 0.022). This provides further evidence that ZNF804A is of functional relevance to schizophrenia and indicates that ZNF804A may be a novel target for pharmacological interventions. |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 54 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 16% |
| Researcher | 8 | 14% |
| Student > Master | 7 | 13% |
| Student > Doctoral Student | 5 | 9% |
| Student > Bachelor | 4 | 7% |
| Other | 10 | 18% |
| Unknown | 13 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 25% |
| Agricultural and Biological Sciences | 10 | 18% |
| Psychology | 9 | 16% |
| Neuroscience | 2 | 4% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Other | 8 | 14% |
| Unknown | 11 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2013.
All research outputs
#7,855,444
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#462
of 1,243 outputs
Outputs of similar age
#44,632
of 127,117 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#6
of 17 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,243 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.