| Title |
The Nudix hydrolase superfamily
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, December 2005
|
| DOI | 10.1007/s00018-005-5386-7 |
| Pubmed ID | |
| Authors |
A. G. McLennan |
| Abstract |
Nudix hydrolases are found in all classes of organism and hydrolyse a wide range of organic pyrophosphates, including nucleoside di- and triphosphates, dinucleoside and diphosphoinositol polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity. Some superfamily members, such as Escherichia coli MicrotT, have the ability to degrade potentially mutagenic, oxidised nucleotides while others control the levels of metabolic intermediates and signalling compounds. In prokaryotes and simple eukaryo tes, the number of Nudix genes varies from 0 to over 30, reflecting the metabolic complexity and adaptability of the organism. Mammals have around 24 Nudix genes, several of which encode more than one variant. This review integrates the sizeable recent literature on these proteins with information from global functional genomic studies to provide some insights into the possible roles of different superfamily members in cellular metabolism and homeostasis and to stimulate discussion and further research into this ubiquitous protein family. |
Mendeley readers
The data shown below were compiled from readership statistics for 414 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 1% |
| United States | 2 | <1% |
| Colombia | 1 | <1% |
| France | 1 | <1% |
| Italy | 1 | <1% |
| New Caledonia | 1 | <1% |
| Bangladesh | 1 | <1% |
| India | 1 | <1% |
| Chile | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 397 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 97 | 23% |
| Researcher | 80 | 19% |
| Student > Master | 50 | 12% |
| Student > Bachelor | 46 | 11% |
| Student > Doctoral Student | 27 | 7% |
| Other | 55 | 13% |
| Unknown | 59 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 163 | 39% |
| Biochemistry, Genetics and Molecular Biology | 101 | 24% |
| Chemistry | 31 | 7% |
| Medicine and Dentistry | 11 | 3% |
| Immunology and Microbiology | 6 | 1% |
| Other | 38 | 9% |
| Unknown | 64 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2023.
All research outputs
#4,965,094
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#928
of 4,151 outputs
Outputs of similar age
#20,192
of 158,140 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#7
of 35 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 158,140 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.