| Title |
Structure–Function Analysis of the ADAM Family of Disintegrin-Like and Metalloproteinase-Containing Proteins (Review)
|
|---|---|
| Published in |
The Protein Journal, May 1999
|
| DOI | 10.1023/a:1020692710029 |
| Pubmed ID | |
| Authors |
Anne L. Stone, Michaela Kroeger, Qing Xiang Amy Sang |
| Abstract |
The ADAMs belong to a disintegrin-like and metalloproteinase-containing protein family that are zinc-dependent metalloproteinases. These proteins share all or some of the following domain structure: a signal peptide, a propeptide, a metalloproteinase, a disintegrin, a cysteine-rich, and an epidermal growth factor (EGF)-like domains, a transmembrane region, and a cytoplasmic tail. ADAMs are widely distributed in many organs, tissues, and cells, such as brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone, and muscle. These proteins are capable of four potential functions: proteolysis, adhesion, fusion, and intracellular signaling. Because the number of ADAM genes has grown rapidly and the biological functions of most members are unclear, this review analyzes the protein structures and functions, their activation and processing, their known and potential activities, and their evolutionary relationships. A sequence alignment of human ADAMs is compiled and their homology and physical data are calculated. The conceivable functions of ADAMs in reproduction, development, and diseases are also discussed. |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 4% |
| United States | 1 | 1% |
| Germany | 1 | 1% |
| Switzerland | 1 | 1% |
| Unknown | 69 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 17% |
| Researcher | 12 | 16% |
| Student > Master | 9 | 12% |
| Student > Bachelor | 8 | 11% |
| Student > Doctoral Student | 7 | 9% |
| Other | 14 | 19% |
| Unknown | 12 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 44% |
| Biochemistry, Genetics and Molecular Biology | 14 | 19% |
| Medicine and Dentistry | 6 | 8% |
| Chemistry | 2 | 3% |
| Veterinary Science and Veterinary Medicine | 1 | 1% |
| Other | 4 | 5% |
| Unknown | 15 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2022.
All research outputs
#3,798,611
of 25,374,647 outputs
Outputs from The Protein Journal
#27
of 639 outputs
Outputs of similar age
#3,023
of 36,590 outputs
Outputs of similar age from The Protein Journal
#1
of 5 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 639 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done particularly well, scoring higher than 93% of its peers.
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