| Title |
Giant reticulospinal synapse in lamprey: molecular links between active and periactive zones
|
|---|---|
| Published in |
Cell and Tissue Research, June 2006
|
| DOI | 10.1007/s00441-006-0216-2 |
| Pubmed ID | |
| Authors |
Lennart Brodin, Oleg Shupliakov |
| Abstract |
Deciphering the function of synaptic release sites is central to understanding neuronal communication. Here, we review studies of the lamprey giant reticulospinal synapse, a model that can be used to dissect synaptic vesicle trafficking at single release sites. The presynaptic axon is large and contains active zones that are spatially separated from each other. During activity, synaptic vesicle membrane is shuttled between the active zone and the periactive zone at which endocytosis occurs. Recent studies have shown that the periactive zone contains an actin-rich cytomatrix that expands during synaptic activity. This cytomatrix has been implicated in multiple functions that include (1) activity-dependent trafficking of proteins between the synaptic vesicle cluster and the periactive zone, (2) synaptic vesicle endocytosis, and (3) the movement of newly formed synaptic vesicles to the vesicle cluster. The actin cytomatrix thus provides a link between the active zone and the periactive zone; this link appears to be critical for sustained cycling of synaptic vesicles. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 33% |
| Student > Ph. D. Student | 14 | 29% |
| Student > Bachelor | 5 | 10% |
| Student > Master | 3 | 6% |
| Student > Doctoral Student | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 7 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 39% |
| Neuroscience | 10 | 20% |
| Medicine and Dentistry | 3 | 6% |
| Business, Management and Accounting | 1 | 2% |
| Mathematics | 1 | 2% |
| Other | 5 | 10% |
| Unknown | 10 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2016.
All research outputs
#7,862,539
of 23,839,820 outputs
Outputs from Cell and Tissue Research
#527
of 2,279 outputs
Outputs of similar age
#23,166
of 65,145 outputs
Outputs of similar age from Cell and Tissue Research
#3
of 18 outputs
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So far Altmetric has tracked 2,279 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
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