| Title |
The mechano-gated K2P channel TREK-1
|
|---|---|
| Published in |
European Biophysics Journal, March 2008
|
| DOI | 10.1007/s00249-008-0318-8 |
| Pubmed ID | |
| Authors |
Alexandra Dedman, Reza Sharif-Naeini, Joost H. A. Folgering, Fabrice Duprat, Amanda Patel, Eric Honoré |
| Abstract |
The versatility of neuronal electrical activity is largely conditioned by the expression of different structural and functional classes of K+ channels. More than 80 genes encoding the main K+ channel alpha subunits have been identified in the human genome. Alternative splicing, heteromultimeric assembly, post-translational modification and interaction with auxiliary regulatory subunits further increase the molecular and functional diversity of K+ channels. Mammalian two-pore domain K+ channels (K(2P)) make up one class of K+ channels along with the inward rectifiers and the voltage- and/or calcium-dependent K+ channels. Each K(2P) channel subunit is made up of four transmembrane segments and two pore-forming (P) domains, which are arranged in tandem and function as either homo- or heterodimeric channels. This novel structural arrangement is associated with unusual gating properties including "background" or "leak" K+ channel activity, in which the channels show constitutive activity at rest. In this review article, we will focus on the lipid-sensitive mechano-gated K(2P) channel TREK-1 and will emphasize on the polymodal function of this "unconventional" K+ channel. |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| France | 1 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 111 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 27% |
| Researcher | 25 | 21% |
| Student > Master | 15 | 13% |
| Student > Bachelor | 9 | 8% |
| Student > Doctoral Student | 8 | 7% |
| Other | 12 | 10% |
| Unknown | 16 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 32% |
| Biochemistry, Genetics and Molecular Biology | 17 | 15% |
| Neuroscience | 12 | 10% |
| Medicine and Dentistry | 12 | 10% |
| Engineering | 7 | 6% |
| Other | 16 | 14% |
| Unknown | 16 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2019.
All research outputs
#4,696,673
of 22,789,566 outputs
Outputs from European Biophysics Journal
#49
of 490 outputs
Outputs of similar age
#15,791
of 81,083 outputs
Outputs of similar age from European Biophysics Journal
#1
of 4 outputs
Altmetric has tracked 22,789,566 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 490 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 81,083 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them