| Title |
Management and consequences of postoperative fluctuations in plasma sodium concentration after pediatric brain tumor surgery in the sellar region: a national cohort analysis
|
|---|---|
| Published in |
Pituitary, April 2018
|
| DOI | 10.1007/s11102-018-0886-2 |
| Pubmed ID | |
| Authors |
R. W. J. Kruis, A. Y. N. Schouten-van Meeteren, M. J. J. Finken, W. Oostdijk, A. S. P. van Trotsenburg, A. M. Boot, H. L. Claahsen-van der Grinten, E. J. van Lindert, K. S. Han, E. W. Hoving, E. M. C. Michiels, H. M. van Santen |
| Abstract |
Severe fluctuations in plasma sodium concentration and plasma osmolarity, including central diabetes insipidus (CDI), may have significant influence on postoperative morbidity and mortality after pediatric brain tumor surgery.The aim of this study was to describe the frequency, severity and neurological consequences of these fluctuations in pediatric brain tumor survivors. A retrospective, multi-institutional chart review was conducted among all children who underwent brain tumor surgery in the sellar or suprasellar region in seven university hospitals in the Netherlands between January 2004 and December 2013. Postoperative CDI was observed in 67.5% of 120 included children. Fluctuations of plasma sodium concentration ≥ 10 mmol/L/24 h during the first ten postoperative days were seen in 75.3% of patients with CDI, with a maximum delta of 46 mmol/L/24 h. When compared to patients without CDI, altered mental status occurred more frequently in patients with postoperative CDI (5.1 vs. 23.5% respectively, p = 0.009). Low plasma sodium concentration was related to altered mental status and the occurrence of seizures. Frequency and severity of fluctuations in plasma sodium concentration during the first ten postoperative days were significantly higher in patients with permanent CDI at last follow-up than in patients with transient CDI or without CDI (p = 0.007). Postoperative CDI is a common complication after pediatric brain tumor surgery in the sellar or suprasellar region. Extreme plasma sodium concentrations and large intra-day fluctuations still occur and seem to influence the postoperative neurological course. These results illustrate the need for intensive monitoring in a highly experienced center. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 21% |
| Other | 5 | 15% |
| Student > Bachelor | 5 | 15% |
| Professor > Associate Professor | 2 | 6% |
| Student > Doctoral Student | 1 | 3% |
| Other | 5 | 15% |
| Unknown | 9 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 35% |
| Biochemistry, Genetics and Molecular Biology | 4 | 12% |
| Neuroscience | 2 | 6% |
| Immunology and Microbiology | 2 | 6% |
| Nursing and Health Professions | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 12 | 35% |
Attention Score in Context
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#16,746,995
of 24,631,014 outputs
Outputs from Pituitary
#305
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#215,242
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Outputs of similar age from Pituitary
#4
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