Title |
Macrophages, pathology and parasite persistence in experimental visceral leishmaniasis
|
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Published in |
Trends in Parasitology, November 2004
|
DOI | 10.1016/j.pt.2004.08.009 |
Pubmed ID | |
Authors |
Christian R. Engwerda, Manabu Ato, Paul M. Kaye |
Abstract |
Many infectious diseases are associated with parasite persistence, often restricted to certain tissue sites, yet the determinants of such persistence are poorly understood. Infection with the protozoan parasite Leishmania donovani has proved a useful experimental tool to address how immune responses can be differentially effective in clearing parasites from different tissues and, conversely, it might also provide a good model for understanding the basis of parasite persistence. This article reviews recent studies on the determinants and consequences of persistent parasite infection in the spleen and suggest that some of the messages to emerge could have important implications for the study of a broad range of infectious diseases. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 7 | 4% |
Germany | 1 | <1% |
France | 1 | <1% |
Portugal | 1 | <1% |
United Kingdom | 1 | <1% |
Belgium | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 184 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 42 | 21% |
Student > Master | 36 | 18% |
Researcher | 26 | 13% |
Student > Doctoral Student | 22 | 11% |
Student > Bachelor | 13 | 7% |
Other | 28 | 14% |
Unknown | 31 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 69 | 35% |
Immunology and Microbiology | 30 | 15% |
Biochemistry, Genetics and Molecular Biology | 19 | 10% |
Medicine and Dentistry | 16 | 8% |
Veterinary Science and Veterinary Medicine | 8 | 4% |
Other | 16 | 8% |
Unknown | 40 | 20% |