Title |
Acquired Methemoglobinemia Associated with Topical Lidocaine Administration: A Case Report
|
---|---|
Published in |
Drug Safety - Case Reports, April 2018
|
DOI | 10.1007/s40800-018-0081-4 |
Pubmed ID | |
Authors |
Hawkins C. Gay, Ansel Philip Amaral |
Abstract |
A 55-year-old male was admitted to the hospital with pneumonia. During an intubation procedure, the patient received an application of endobronchial lidocaine (4% gel). Within 2 h of intubation, the patient developed worsening hypoxia, and investigation of arterial blood gasses revealed a pH of 7.21, carbon dioxide partial pressure (PaCO2) of 3.3 kPa, oxygen partial pressure (PaO2) of 55.1 kPa, and measured oxygen saturation of 49%. Co-oximetry of this sample returned a methemoglobin level of 53%. Intravenous methylthioninium chloride (1% solution at 1 mg/kg) was delivered, and subsequent arterial blood gasses, at 30 min and 1 h post administration, showed methemoglobin levels of 12 and 9%, respectively, with return of oxygen saturation to > 90%. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 1 | 8% |
Student > Doctoral Student | 1 | 8% |
Student > Bachelor | 1 | 8% |
Student > Ph. D. Student | 1 | 8% |
Researcher | 1 | 8% |
Other | 1 | 8% |
Unknown | 6 | 50% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 33% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Unknown | 7 | 58% |