Kinase Inhibitors

Chapter 1 Targeting Cancer with Small-Molecular-Weight Kinase Inhibitors.

Chapter 2 Small-Molecule Protein and Lipid Kinase Inhibitors in Inflammation and Specific Models for Their Evaluation

Chapter 3 Measuring the Activity of Leucine-Rich Repeat Kinase 2: A Kinase Involved in Parkinson’s Disease

Chapter 4 Measuring PI3K Lipid Kinase Activity

Chapter 5 A Fluorescence Polarization Assay for the Discovery of Inhibitors of the Polo-Box Domain of Polo-Like Kinase 1

Chapter 6 Assessment of Hepatotoxicity Potential of Drug Candidate Molecules Including Kinase Inhibitors by Hepatocyte Imaging Assay Technology and Bile Flux Imaging Assay Technology

Chapter 7 Kinase Inhibitors

Chapter 8 Chemoproteomic characterization of protein kinase inhibitors using immobilized ATP.

Chapter 9 Proteome-Wide Identification of Staurosporine-Binding Kinases Using Capture Compound Mass Spectrometry

Chapter 10 Affinity Purification of Proteins Binding to Kinase Inhibitors Immobilized on Self-Assembling Monolayers

Chapter 11 Kinase Inhibitor Profiling Using Chemoproteomics

Chapter 12 Covalent cross-linking of kinases with their corresponding peptide substrates.

Chapter 13 Receptor Tyrosine Kinase Inhibitor Profiling Using Bead-Based Multiplex Sandwich Immunoassays

Chapter 14 Monitoring Phosphoproteomic Response to Targeted Kinase Inhibitors Using Reverse-Phase Protein Microarrays

Chapter 15 Measuring Phosphorylation-Specific Changes in Response to Kinase Inhibitors in Mammalian Cells Using Quantitative Proteomics

Chapter 16 Investigation of Acquired Resistance to EGFR-Targeted Therapies in Lung Cancer Using cDNA Microarrays