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Cancer Neutron Capture Therapy

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Cover of 'Cancer Neutron Capture Therapy'

Table of Contents

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    Book Overview
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    Chapter 1 Selective Thermal Neutron Capture Therapy of Cancer Cells Using their Specific Metabolic Activities—Melanoma as Prototype
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    Chapter 2 Recent Results with Liposomes as Boron Delivery Vehicles for Boron Neutron Capture Therapy
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    Chapter 3 Preparation of Epidermal Growth Factor Conjugates Aimed for Boron Neutron Capture Therapy
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    Chapter 4 Epidermal Growth Factor (EGF) as a Potential Targeting Agent for Delivery of Boron to Malignant Gliomas
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    Chapter 5 Boron Neutron Capture Therapy Against Tumor Cells with Overexpression of the EGF-Receptor
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    Chapter 6 Boron-Rich Oligophosphates — Novel Molecules for Use in BNCT
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    Chapter 7 Potential Use of Bispecific Antibodies (BSABS) for Targeting Gliomas and Melanomas
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    Chapter 8 Effect of Intratumoral Injection of 10 B-Immunoliposome on BNCT for Growth Inhibition of Human Pancreatic Cancer Grafts in Nude Mice
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    Chapter 9 Chemical Modeling with p -Boronophenylalanine for Boron Accumulation to and Release from Melanoma
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    Chapter 10 Chemical Properties of p -, m -, o -Boronophenylalanine
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    Chapter 11 An Efficient Synthesis of p -Boronophenylalanine and Its Homologues by the Reaction of Ethyl Isocyanoacetate with a p -Formylbenzeneboronic Acid Derivative
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    Chapter 12 New Unnatural Boron-Containing Amino Acids and Peptides as Potential Delivery Agents for Neutron Capture Therapy
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    Chapter 13 Study of the Interaction of P-Boronophenylalanine and Its Analogs with Various Carboxylic Acids by Using Zone Electrophoresis
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    Chapter 14 Examination of Stability of p- , m- , o- Boronophenylalanine in Blood with High Performance Liquid Chromatography
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    Chapter 15 Synthesis and Initial Biological Evaluation of Carborane-Containing Phenanthridinium Derivatives
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    Chapter 16 Chemical Behavior of Boron-Containing Amino Acids for Neutron Capture Therapy in Aqueous Solutions
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    Chapter 17 Asymmetric Synthesis of o - and p -Carboranyl Amino Acids
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    Chapter 18 Synthesis, Tissue Uptake, and Toxicity of a Nickel Tetracarboranylphenylporphyrin
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    Chapter 19 Optimization of Drug Anchor for Ortho -Carborane in Reconstitution of Low Density Lipoproteins for Neutron Capture Therapy
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    Chapter 20 Synthesis of 5-S-Alkylcarboranyl-2′-Deoxyuridines
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    Chapter 21 Synthesis of Boronated Uridine Derivatives for Boron Neutron Capture Therapy
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    Chapter 22 New Small Molecular Weight Agents for Boron Neutron Capture Therapy
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    Chapter 23 Synthesis and Biochemical Evaluation of 5-Tethered Boron-Containing Pyrimidine Nucleosides for BNCT
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    Chapter 24 Synthesis of a Water-Soluble o-Carborane Bearing Uracil Moiety Via Palladium Catalyzed Reaction under Essentially Neutral Conditions
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    Chapter 25 Netropsin and Distamycin Analogues Bearing Ortho-Carborane
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    Chapter 26 Spatial and Temporal Distribution of Boron Uptake in Excised Samples of Human Rheumatoid Synovium
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    Chapter 27 Analysis of Boron in LDL-Matrix
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    Chapter 28 Non-Linear Regression between Track Density and 10 B Concentration in Photo-Electronic Neutron Capture Radiography
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    Chapter 29 New Developments in the Use of Solid State Nuclear Track Detectors
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    Chapter 30 Subcellular Localization of a Boronated Nucleoside Using Ion Microscopy
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    Chapter 31 Ion Microscopy Imaging of Boron from BNCT Drugs in Cryogenically Prepared Tissues
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    Chapter 32 Application of Neutron-Induced Prompt Gamma-Ray Analysis for Determination of B-10 in BNCT
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    Chapter 33 Foundations for Boron Neutron Capture Therapy of High-Grade Astrocytomas
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    Chapter 34 Noninvasive in-vivo Detection of Boron-10 by Magnetic Resonance
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    Chapter 35 Determination of Mn-BOPP Concentrations Using Neutron Activation Analysis and MRI
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    Chapter 36 Boron-, Gadolinium-Porphyrin Derivatives for Neutron Capture Therapy
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    Chapter 37 The Measurement of Gadolinium Concentration in Rat Brain Tumor with NMR Analyzer for Neutron Capture Therapy
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    Chapter 38 Procedures for the Medical Application of Research Reactors
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    Chapter 39 On-Line Beam Monitoring for Boron Neutron Capture Therapy at the MIT Research Reactor
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    Chapter 40 Status of the BNCT Project at the HFR Petten
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    Chapter 41 Physics of Boron Neutron Capture Therapy in Japan
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    Chapter 42 Improvements in Patient Treatment Planning Systems
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    Chapter 43 Monte Carlo Neutron Photon Treatment Planning Calculations
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    Chapter 44 Validation of Monte Carlo Dose Planning Calculations by Epithermal Beam Dose Distribution Measurements in Phantoms
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    Chapter 45 Design Study on Triangular-Hexagonal Triga Core for Epithermal Neutron Irradiation
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    Chapter 46 Development of the ECN Argonaut Reactor for BNCT Studies
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    Chapter 47 The Boron Neutron Capture Therapy Research Facility at the Tehran Research Reactor (TRR)
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    Chapter 48 Epithermal Neutron Beam Design for Neutron Capture Therapy at Tsing Hua Open-Pool Reactor
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    Chapter 49 Upgrades of the Epithermal Neutron Beam at the Brookhaven Medical Research Reactor
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    Chapter 50 A Direct Comparison of Neutron Energy Spectra at High and Low Powers in the HB11 Beam at H.F.R. Petten
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    Chapter 51 Conceptual Design for an Epithermal-Neutron Beam for Boron Neutron Capture Therapy at the Georgia Institute of Technology Research Reactor
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    Chapter 52 Remodeling of the Heavy-Water Facility of the Kyoto University Reactor for Epithermal and Thermal Neutrons
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    Chapter 53 The Utilization of Hyper-Thermal Neutrons for Neutron Capture Therapy
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    Chapter 54 Epithermal-Neutron Beam Design for Neutron Capture Therapy at the Tsing-Hua Open Pool Reactor (THOR)
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    Chapter 55 The IEC Neutron Generator and Filter Concept for Neutron Capture Therapy
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    Chapter 56 Capillary Neutron Optics for Boron Neutron Capture Therapy
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    Chapter 57 High-Intensity Fission-Converter-Based Epithermal Neutron Beam for Neutron Capture Therapy
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    Chapter 58 A Study of the Concept of a Fission-Plate Converter as a Source for an Epithermal Neutron Beam
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    Chapter 59 Design of Epithermal Neutron Beams Using Spent Fuel Elements at the Musashi Reactor
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    Chapter 60 An Accelerator-Based Epithermal Photoneutron Source for BNCT
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    Chapter 61 Conceptual Design of a Deuteron Linac Facility for Boron Neutron Capture Therapy
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    Chapter 62 Shielding Design and Dose Assessment for an Accelerator-Based BNCT Facility
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    Chapter 63 Neutron Generator as a Neutron Source for BNCT
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    Chapter 64 Beam Profiles of an Epithermal Neutron Beam
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    Chapter 65 Mixed Field Dosimetry of Neutron Beams for Boron Neutron Capture Therapy at the Massachusetts Institute of Technology
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    Chapter 66 Determination of Boron Dose for BNCT Using Fricke and EPR Dosimetry
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    Chapter 67 Simultaneous Monitoring System of Neutron Fluence Rate Distribution by Detectors with Multiple Sensitive Heads
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    Chapter 68 Dose Sparing of Capillary Endothelial Cells for BSH and BPA
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    Chapter 69 A Microdosimetry Model for BNCT Analysis
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    Chapter 70 A Microdosimetry Model for In Vitro Boron Neutron Capture Irradiation Experiments Using d(14)+Be-Neutrons
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    Chapter 71 Computational Dosimetry of BNCT for Breast Cancer Treatment
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    Chapter 72 Phantoms for Neutron Capture Therapy Dosimetry
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    Chapter 73 Measurements of Depth-Dose Distributions in a Phantom for Gadolinium Neutron Capture Therapy
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    Chapter 74 Theoretical Evaluation of the Dose Distribution for Gadolinium Neutron Capture Therapy
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    Chapter 75 Calculated Electron Spectra for Gadolinium Neutron Capture Therapy
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    Chapter 76 Biologic Considerations in Targeting Brain tumors for Boron Neutron Capture Therapy
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    Chapter 77 T1 Measurement to Study the Penetration of BNCT Agents Into Canine Tumors Caused by Blood Brain Barrier Damage
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    Chapter 78 Enhanced Tumor Uptake of Boronophenylalanine by Means of Osmotic Blood-Brain Barrier Disruption in Glioma—Bearing Rats
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    Chapter 79 Boron Neutron Capture Therapy of Glioblastoma Multiforme Using the p -Boronophenylalanine-Fructose Complex and Epithermal Neutrons
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    Chapter 80 The Dose Planning of BNCT for Brain Tumors
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    Chapter 81 Effectiveness of Borocaptate Sodium for Boron Neutron Capture Therapy in Malignant Brain Tumors
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    Chapter 82 Evaluation of Response to Thermal Neutron Irradiation in Quiescent Cell Populations Within Murine Solid Tumors Using Micronucleus Assay
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    Chapter 83 Assessment of Radiation Induced Damage of Mouse Brain Using 18 F-2-Deoxy-D-Glucose and 99m Tc-Hexamethylpropylene Amine Oxine
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    Chapter 84 Brain Tolerance in Dogs to Boron Neutron Capture Therapy with Borocaptate Sodium (BSH) or Boronophenylalanine (BPA)
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    Chapter 85 Pharmacokinetics and Effects of Neutron Capture on Melanoma Xenografts after Administration of Boronated Low Density Lipoprotein
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    Chapter 86 Toxicology and Pharmacokinetics of BOPP in a Canine Model
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    Chapter 87 Acute Toxicity of Elaidyl-1,2,-Carborane Carboxylate (ECC) in Rats
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    Chapter 88 ESR Study of Hydroxyl Radicals, Superoxide Anion Radicals and Molecular Singlet Oxygen Generated by Mercaptoundecahydro- closo -Dodecaborate(2-) Solution Irradiated by Neutrons under Conditions of Boron Neutron Capture Reaction
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    Chapter 89 Boron Neutron Capture Therapy of Uveal Melanoma
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    Chapter 90 Binding and Immunohistochemical Localization of Na 2 B 12 H 11 SH to Tumor Tissue of Glioma Patients in Boron Neutron Capture Therapy
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    Chapter 91 Pharmacokinetics and Biodistribution in Patients with Malignant Glioma after Administration of N-Acetylcysteine (N-AC) Prior to Borocaptate Sodium (BSH)
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    Chapter 92 Additional Impurities Identified in Borocaptate Sodium
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    Chapter 93 Uptake and Distribution of the Boron Containing Ether Lipid B-ET-11-OMe in Tumor Bearing Mice
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    Chapter 94 Uptake and Biological Effects of the Carborane Based Boron Compounds DAC-1 and DAAC-1
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    Chapter 95 BNCT of Malignant Melanoma-Radiobiological Analysis and Data Comparison with Conventional Radiotherapy
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    Chapter 96 Re-Evaluation of Skin RBE for Clinical BNCT of Malignant Melanoma
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    Chapter 97 Boron Analytical Studies on 10 B 1 -BPA Administration for Neutron Capture Therapy of Malignant Melanoma
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    Chapter 98 Pharmacokinetic Comparison Between L & D, L-BPA. Fructose in a Murine Melanoma Model and in Human Patients with Metastatic Melanoma
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    Chapter 99 A Basic Concept for PET-BNCT System
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    Chapter 100 Two Cases of Primary Malignant Melanoma Treated by Selective Melanoma Thermal Neutron Capture Therapy
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    Chapter 101 A Phase-I Dose-Escalation Trial of Boron Neutron Capture Therapy for Subjects with Metastatic Subcutaneous Melanoma of the Extremities
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    Chapter 102 Recent Study of Boron Neutron Capture Therapy for Malignant Brain Tumor in Japan
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    Chapter 103 Boron Neutron Capture Therapy for Malignant Brain Tumors in Children
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    Chapter 104 Blood-Brain Barrier Disruption (BBB-D) in Rats
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    Chapter 105 A Phase 1 Trial of Intravenous Boronophenylalanine-Fructose Complex in Patients with Glioblastoma Multiforme
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    Chapter 106 BNCT Microdosimetry and Brain-Tumor Patient Response
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    Chapter 107 The Therapeutic Ratio in BNCT
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    Chapter 108 Boron Neutron Capture Therapy of Spontaneous Intracranial Tumors in Dogs
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    Chapter 109 Sodium Borocaptate and Boronopheynlalanine Alone or in Combination as Capture Agents for BNCT of the F98 Rat Glioma
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    Chapter 110 BNCT as an Adjuvant to Fast Neutron Radiotherapy for Selected Tumor Systems
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    Chapter 111 Development of a Method to Use Boron Neutron Capture Therapy for Diffused Tumours of Liver (Taormina Project)
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    Chapter 112 Evidence for a Null Effect of L- 10 BPA Neutron Capture Therapy on Mouse Brain Dopamine Tracts
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    Chapter 113 Microvasculature Casting Technique for Capillary Endothelial Damage after BNCT
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    Chapter 114 Normal Tissue Tolerance and Fractionation Effects in Dogs of Boron Neutron Capture Irradiation with Borocaptate Sodium (BSH)
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    Chapter 115 The Compound Factor of NA 2 B 12 H 11 SH and the Relative Biological Effectiveness of Recoil Protons for Neurological Damage in Boron Neutron Capture Therapy
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    Chapter 116 Positron Emission Tomography and Boron Neutron Capture Therapy System to the Patient with Malignant Brain Tumor
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    Chapter 117 Selective Detection of Brain Metastasis of Malignant Melanoma Using 18 F- 10 B-L-Borono-Phenylalanine with Positron Emission Tomography
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    Chapter 118 In Vivo NMR Evaluation of the Pharmacokinetics of Boronated Compounds in the Rat Model
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    Chapter 119 Boron MRI in a Tumor Bearing Canine Model
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    Chapter 120 First Boron MRI of a Human Patient with a Brain Tumor
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    Chapter 121 Assessment of Photon Contributions in Gadolinium Neutron Capture Reactions-A Preliminary Study
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    Chapter 122 Gadolinium Neutron Capture Therapy (GdNCT) with MRI Contrast Media. In Vitro Studies
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    Chapter 123 Neutron Capture Therapy with Gd-DTPA in Tumor-Bearing Rats
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    Chapter 124 Clinical Californium-252 Boron Neutron Capture Enhancement
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    Chapter 125 Dedication to the Memory of Professor Hiroshi Hatanaka
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    Chapter 126 Noted Authority on Neutron Therapy Dies in January 1995
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Title
Cancer Neutron Capture Therapy
Published by
Springer US, June 2013
DOI 10.1007/978-1-4757-9567-7
ISBNs
978-1-4757-9569-1, 978-1-4757-9567-7
Editors

Mishima, Yutaka

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Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 29%
Student > Bachelor 1 14%
Student > Doctoral Student 1 14%
Other 1 14%
Unknown 2 29%
Readers by discipline Count As %
Physics and Astronomy 2 29%
Biochemistry, Genetics and Molecular Biology 1 14%
Chemistry 1 14%
Medicine and Dentistry 1 14%
Unknown 2 29%