Title |
Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies
|
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Published in |
Journal of neurology, neurosurgery and psychiatry, April 2000
|
DOI | 10.1136/jnnp.68.4.423 |
Pubmed ID | |
Authors |
G Giovannoni, J D O'Sullivan, K Turner, A J Manson, A J Lees |
Abstract |
Hedonistic homeostatic dysregulation is a neuropsychological behavioural disorder associated with substance misuse and addiction. The disorder has been recognised as a consequence of dopamine replacement therapy (DRT) in 15 patients with Parkinson's disease. The syndrome typically develops in male patients with early onset Parkinson's disease, and can occur with orally and subcutaneously administered DRT. These patients take increasing quantities of their DRT, despite increasingly severe drug induced dyskinesias, and may develop a cyclical mood disorder with hypomania or manic psychosis. There is impairment of social and occupational functioning. Tolerance develops to mood elevating effects of DRT and a negative affective withdrawal state occurs if the drugs are withdrawn or doses decreased. The clinical features and guidelines for managing this syndrome are discussed. A set of diagnostic criteria for further investigating this condition is proposed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 5 | 83% |
Unknown | 1 | 17% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 50% |
Members of the public | 2 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 4 | 2% |
Switzerland | 2 | <1% |
United States | 2 | <1% |
United Kingdom | 2 | <1% |
Italy | 1 | <1% |
Germany | 1 | <1% |
Finland | 1 | <1% |
Slovenia | 1 | <1% |
Canada | 1 | <1% |
Other | 0 | 0% |
Unknown | 206 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 36 | 16% |
Student > Ph. D. Student | 34 | 15% |
Student > Master | 26 | 12% |
Student > Bachelor | 25 | 11% |
Student > Doctoral Student | 17 | 8% |
Other | 54 | 24% |
Unknown | 29 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 70 | 32% |
Psychology | 48 | 22% |
Neuroscience | 33 | 15% |
Agricultural and Biological Sciences | 10 | 5% |
Social Sciences | 4 | 2% |
Other | 8 | 4% |
Unknown | 48 | 22% |