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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
|
|---|---|
| Published in |
Nature Genetics, October 2007
|
| DOI | 10.1038/ng.2007.17 |
| Pubmed ID | |
| Authors |
Jeffrey C Barrett, Paul R Burton, Dan Davison, Peter Donnelly, Doug Easton, David M Evans, Hin-Tak Leung, Jonathan L Marchini, Andrew P Morris, Chris CA Spencer, Martin D Tobin, Lon R Cardon, David G Clayton, Antony P Attwood, James P Boorman, Barbara Cant, Ursula Everson, Judith M Hussey, Jennifer D Jolley, Alexandra S Knight, Kerstin Koch, Elizabeth Meech, Sarah Nutland, Christopher V Prowse, Helen E Stevens, Niall C Taylor, Graham R Walters, Neil M Walker, Nicholas A Watkins, Thilo Winzer, John A Todd, Willem H Ouwehand, Richard W Jones, Wendy L McArdle, Susan M Ring, David P Strachan, Marcus Pembrey, Gerome Breen, David St Clair, Sian Caesar, Katharine Gordon-Smith, Lisa Jones, Christine Fraser, Elaine K Green, Detelina Grozeva, Marian L Hamshere, Peter A Holmans, Ian R Jones, George Kirov, Valentina Moskivina, Ivan Nikolov, Michael C O'Donovan, Michael J Owen, Nick Craddock, David A Collier, Amanda Elkin, Anne Farmer, Richard Williamson, Peter McGuffin, Allan H Young, I Nicol Ferrier, Stephen G Ball, Anthony J Balmforth, Jennifer H Barrett, Timothy D Bishop, Mark M Iles, Azhar Maqbool, Nadira Yuldasheva, Alistair S Hall, Peter S Braund, Paul R Burton, Richard J Dixon, Massimo Mangino, Suzanne Stevens, Martin D Tobin, John R Thompson, Nilesh J Samani, Francesca Bredin, Mark Tremelling, Miles Parkes, Hazel Drummond, Charles W Lees, Elaine R Nimmo, Jack Satsangi, Sheila A Fisher, Alastair Forbes, Cathryn M Lewis, Clive M Onnie, Natalie J Prescott, Jeremy Sanderson, Christopher G Matthew, Jamie Barbour, M Khalid Mohiuddin, Catherine E Todhunter, John C Mansfield, Tariq Ahmad, Fraser R Cummings, Derek P Jewell, John Webster, Morris J Brown, David G Clayton, Mark G Lathrop, John Connell, Anna Dominiczak, Nilesh J Samani, Carolina A Braga Marcano, Beverley Burke, Richard Dobson, Johannie Gungadoo, Kate L Lee, Patricia B Munroe, Stephen J Newhouse, Abiodun Onipinla, Chris Wallace, Mingzhan Xue, Mark Caulfield, Martin Farrall, Anne Barton, Ian N Bruce, Hannah Donovan, Steve Eyre, Paul D Gilbert, Samantha L Hilder, Anne M Hinks, Sally L John, Catherine Potter, Alan J Silman, Deborah PM Symmons, Wendy Thomson, Jane Worthington, David G Clayton, David B Dunger, Sarah Nutland, Helen E Stevens, Neil M Walker, Barry Widmer, John A Todd, Timothy M Frayling, Rachel M Freathy, Hana Lango, John R B Perry, Beverley M Shields, Michael N Weedon, Andrew T Hattersley, Graham A Hitman, Mark Walker, Kate S Elliott, Christopher J Groves, Cecilia M Lindgren, Nigel W Rayner, Nicolas J Timpson, Eleftheria Zeggini, Mark I McCarthy, Melanie Newport, Giorgio Sirugo, Emily Lyons, Fredrik Vannberg, Adrian V S Hill, Linda A Bradbury, Claire Farrar, Jennifer J Pointon, Paul Wordsworth, Matthew A Brown, Jayne A Franklyn, Joanne M Heward, Matthew J Simmonds, Stephen CL Gough, Sheila Seal, Michael R Stratton, Nazneen Rahman, Maria Ban, An Goris, Stephen J Sawcer, Alastair Compston, David Conway, Muminatou Jallow, Melanie Newport, Giorgio Sirugo, Kirk A Rockett, Dominic P Kwiatkowski, Suzannah J Bumpstead, Amy Chaney, Kate Downes, Mohammed JR Ghori, Rhian Gwilliam, Sarah E Hunt, Michael Inouye, Andrew Keniry, Emma King, Ralph McGinnis, Simon Potter, Rathi Ravindrarajah, Pamela Whittaker, Claire Widden, David Withers, Panos Deloukas, Hin-Tak Leung, Sarah Nutland, Helen E Stevens, Neil M Walker, John A Todd, Doug Easton, David G Clayton, Paul R Burton, Martin D Tobin, Jeffrey C Barrett, David M Evans, Andrew P Morris, Lon R Cardon, Niall J Cardin, Dan Davison, Teresa Ferreira, Joanne Pereira-Gale, Ingeleif B Hallgrimsdóttir, Bryan N Howie, Jonathan L Marchini, Chris CA Spencer, Zhan Su, Yik Ying Teo, Damjan Vukcevic, Peter Donnelly, David Bentley, Matthew A Brown, Lon R Cardon, Mark Caulfield, David G Clayton, Alastair Compston, Nick Craddock, Panos Deloukas, Peter Donnelly, Martin Farrall, Stephen CL Gough, Alistair S Hall, Andrew T Hattersley, Adrian V S Hill, Dominic P Kwiatkowski, Christopher G Matthew, Mark I McCarthy, Willem H Ouwehand, Miles Parkes, Marcus Pembrey, Nazneen Rahman, Nilesh J Samani, Michael R Stratton, John A Todd, Jane Worthington, Sarah L Mitchell, Paul R Newby, Oliver J Brand, Jackie Carr-Smith, Simon H S Pearce, Stephen C L Gough, R McGinnis, A Keniry, P Deloukas |
| Abstract |
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing spondylitis, ARTS1 and IL23R, and confirmation of the previously reported association of AITD with TSHR and FCRL3. These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 548 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 10 | 2% |
| United States | 8 | 1% |
| Germany | 4 | <1% |
| France | 3 | <1% |
| Italy | 1 | <1% |
| Canada | 1 | <1% |
| Australia | 1 | <1% |
| Russia | 1 | <1% |
| Iceland | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 518 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 130 | 24% |
| Student > Ph. D. Student | 103 | 19% |
| Student > Master | 48 | 9% |
| Other | 42 | 8% |
| Professor | 37 | 7% |
| Other | 113 | 21% |
| Unknown | 75 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 166 | 30% |
| Medicine and Dentistry | 141 | 26% |
| Biochemistry, Genetics and Molecular Biology | 60 | 11% |
| Immunology and Microbiology | 22 | 4% |
| Computer Science | 13 | 2% |
| Other | 56 | 10% |
| Unknown | 90 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2023.
All research outputs
#1,435,674
of 26,017,215 outputs
Outputs from Nature Genetics
#2,169
of 7,655 outputs
Outputs of similar age
#2,847
of 92,483 outputs
Outputs of similar age from Nature Genetics
#9
of 55 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,655 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.8. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 92,483 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.