| Title |
Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts Type II diabetes independent of insulin resistance
|
|---|---|
| Published in |
Diabetologia, November 2000
|
| DOI | 10.1007/s001250051560 |
| Pubmed ID | |
| Authors |
C. Weyer, J. E. Foley, C. Bogardus, P. A. Tataranni, R. E. Pratley |
| Abstract |
Cross-sectional studies indicate that enlarged subcutaneous abdominal adipocyte size is associated with hyperinsulinaemia, insulin resistance and glucose intolerance. To further explore the pathophysiological significance of these associations, we examined prospectively whether enlarged subcutaneous abdominal adipocyte size predicts Type II (non-insulin-dependent) diabetes mellitus. Body composition (hydrodensitometry), mean subcutaneous abdominal adipocyte size (fat biopsy), insulin sensitivity (hyperinsulinaemic clamp) and the acute insulin secretory response (25-g i.v. GTT) were assessed in 280 Pima Indians with either normal (NGT), impaired (IGT) or diabetic glucose tolerance (75-g OGTT). Subjects with NGT were then followed prospectively. After adjusting for age, sex and per cent body fat, mean subcutaneous abdominal adipocyte size was 19% and 11% higher in subjects with diabetes and IGT, compared with those with NGT (p < 0.001). Insulin sensitivity was inversely correlated with mean subcutaneous abdominal adipocyte size (r = -0.53, p < 0.0001), even after adjusting for per cent body fat (r = -0.31, p < 0.001). In 108 NGT subjects followed over 9.3 +/- 4.1 years (33 of whom developed diabetes), enlarged mean subcutaneous abdominal adipocyte size but not high per cent body fat, was an independent predictor of diabetes, in addition to a low insulin sensitivity and acute insulin secretory response [relative hazard 10th vs 90th centile (95% CI): 5.8 (1.7-19.6), p < 0.005]. In 28 NGT subjects with a 9% weight gain over 2.7 +/- 1.3 years, changes in insulin sensitivity were inversely and independently related to changes in mean subcutaneous abdominal adipocyte size and per cent body fat. Although enlarged mean subcutaneous abdominal adipocyte size is associated with insulin resistance cross-sectionally, prospectively, both abnormalities are independent and additive predictors of Type II diabetes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iceland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 255 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Malaysia | 1 | <1% |
| Netherlands | 1 | <1% |
| New Zealand | 1 | <1% |
| United Kingdom | 1 | <1% |
| Greece | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 246 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 21% |
| Researcher | 37 | 15% |
| Student > Bachelor | 26 | 10% |
| Student > Master | 21 | 8% |
| Professor > Associate Professor | 13 | 5% |
| Other | 48 | 19% |
| Unknown | 57 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 63 | 25% |
| Agricultural and Biological Sciences | 47 | 18% |
| Biochemistry, Genetics and Molecular Biology | 34 | 13% |
| Nursing and Health Professions | 11 | 4% |
| Sports and Recreations | 6 | 2% |
| Other | 25 | 10% |
| Unknown | 69 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 November 2017.
All research outputs
#3,660,444
of 25,837,817 outputs
Outputs from Diabetologia
#1,709
of 5,621 outputs
Outputs of similar age
#3,739
of 42,064 outputs
Outputs of similar age from Diabetologia
#4
of 15 outputs
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