Therapeutic Applications of Ribozymes and Riboswitches

Chapter 1 Identification of regulatory RNA in bacterial genomes by genome-scale mapping of transcription start sites.

Chapter 2 Screening Inhibitory Potential of Anti-HIV RT RNA Aptamers

Chapter 3 Design and Evaluation of Clinically Relevant SOFA-HDV Ribozymes Targeting HIV RNA

Chapter 4 Directing RNase P-Mediated Cleavage of Target mRNAs by Engineered External Guide Sequences in Cultured Cells

Chapter 5 Design and Analysis of Hammerhead Ribozyme Activity Against an Artificial Gene Target

Chapter 6 Knockdown Strategies for the Study of Proprotein Convertases and Proliferation in Prostate Cancer Cells

Chapter 7 Use of Tumor-Targeting Trans -Splicing Ribozyme for Cancer Treatment

Chapter 8 Characterization of Hairpin Ribozyme Reactions

Chapter 9 Finding Instances of Riboswitches and Ribozymes by Homology Search of Structured RNA with Infernal

Chapter 10 Structure-Based Virtual Screening for the Identification of RNA-Binding Ligands

Chapter 11 Probing Riboswitch Binding Sites with Molecular Docking, Focused Libraries, and In-line Probing Assays

Chapter 12 Discovery of Small Molecule Modifiers of microRNAs for the Treatment of HCV Infection

Chapter 13 Bacterial Flavin Mononucleotide Riboswitches as Targets for Flavin Analogs

Chapter 14 Construction and Application of Riboswitch-Based Sensors That Detect Metabolites Within Bacterial Cells

Chapter 15 Screening Assays to Identify Artificial glmS Ribozyme Activators

Chapter 16 Analysis of Riboswitch Structure and Ligand Binding Using Small-Angle X-ray Scattering (SAXS)

Chapter 17 Use of SHAPE to Select 2AP Substitution Sites for RNA–Ligand Interactions and Dynamics Studies

Chapter 18 Cell Internalization SELEX: In Vitro Selection for Molecules That Internalize into Cells

Chapter 19 Therapeutic Applications of Ribozymes and Riboswitches