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Biological Reactive Intermediates IV

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Cover of 'Biological Reactive Intermediates IV'

Table of Contents

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    Book Overview
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    Chapter 1 Cytochrome P-450 Oxidations and the Generation of Biologically Reactive Intermediates
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    Chapter 2 Formation of Reactive Intermediates by Phase II Enzymes: Glutathione-Dependent Bioactivation Reactions
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    Chapter 3 Role of the Well-Known Basic and Recently Discovered Acidic Glutathione S-Transferases in the Control of Genotoxic Metabolites
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    Chapter 4 Bioactivation of Xenobiotics by Flavin-Containing Monooxygenases
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    Chapter 5 Formation of Biological Reactive Intermediates by Peroxidases: Halide Mediated Acetaminophen Oxidation and Cytotoxicity
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    Chapter 6 Peroxyl Free Radicals: Biological Reactive Intermediates Produced during Lipid Oxidation
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    Chapter 7 Biological Significance of Active Oxygen Species: In Vitro Studies on Singlet Oxygen-Induced DNA Damage and on the Singlet Oxygen Quenching Ability of Carotenoids, Tocopherols and Thiols
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    Chapter 8 Physiological and Toxicological Roles of Hydroperoxides
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    Chapter 9 Overview: Theoretical Aspects of Isotope Effects on the Pattern of Metabolites Formed by Cytochrome P-450
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    Chapter 10 S-Thiolation of Protein Sulfhydryls
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    Chapter 11 Cytochrome P-450 as a Target of Biological Reactive Intermediates
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    Chapter 12 Hapten Carrier Conjugates Associated with Halothane Hepatitis
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    Chapter 13 Metabolism of Drugs by Activated Leukocytes: Implications for Drug-Induced Lupus and Other Drug Hypersensitivity Reactions
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    Chapter 14 Formation of Reactive Metabolites and Appearance of Antiorganelle Antibodies in Man
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    Chapter 15 Formation of a Protein-Acetaldehyde Adduct in Liver during Chronic Alcohol Exposure
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    Chapter 16 Dose-Response Relationships in Chemical Carcinogenesis: From DNA Adducts to Tumor Incidence
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    Chapter 17 The Single Cell Gel (SCG) Assay: An Electrophoretic Technique for the Detection of DNA Damage in Individual Cells
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    Chapter 18 Monitoring Human Exposure to Environmental Carcinogens
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    Chapter 19 Comparing the Frequency and Spectra of Mutations Induced When an SV40-Based Shuttle Vector Containing Covalently Bound Residues of Structurally-Related Carcinogens Replicates in Human Cells
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    Chapter 20 Molecular Targets of Chemical Mutagens
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    Chapter 21 Mutagenic Consequences of the Alteration of DNA by Chemicals and Radiation
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    Chapter 22 Gene Specific Damage and Repair after Treatment of Cells with UV and Chemotherapeutical Agents
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    Chapter 23 Proto-oncogene activation in rodent and human tumors.
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    Chapter 24 Toxicity of 3-Methyleneoxindole, a Proposed Reactive Intermediate in the Metabolism of 3-Methylindole
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    Chapter 25 The Role of Cytochrome P450IIE1 in Bioactivation of Acetaminophen in Diabetic and Acetone-Treated Mice
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    Chapter 26 Arylamine-Induced Hemolytic Anemia: Electron Spin Resonance Spectrometry Studies
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    Chapter 27 Selective Alterations in the Profiles of Newly Synthesized Proteins by Acetaminophen (APAP) and its Dimethylated Analogues: Relationship to Oxidative Stress
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    Chapter 28 Benzene Metabolism by Two Purified, Reconstituted Rat Hepatic Mixed Function Oxidase Systems
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    Chapter 29 Stereochemical Induction of Cytochrome P450IVA1 (P452) and Peroxisome Proliferation in Male Rat
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    Chapter 30 Cyanide Liberation and Oxidative Stress by Organothiocyanates, Organonitriles and Nitroprusside in Isolated Hepatocytes
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    Chapter 31 Mixed Function Oxidase Enzyme Responses to in Vivo and in Vitro Chromate Treatment
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    Chapter 32 Fatty Acid β-Oxidation-Dependent Bioactivation of 5,6-Dichloro-4-Thia-5-Hexenoate and Analogs in Isolated Rat Hepatocytes
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    Chapter 33 Role of the Acetone Inducible P-450IIE1 in the Deethylation of Diethylnitrosamine in Hamster
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    Chapter 34 Stereochemistry of the Microsomal Glutathione S -Transferase-Catalyzed Addition of Glutathione to Chlorotrifluoroethene in Isolated Rat Hepatocytes
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    Chapter 35 The Pathophysiological Significance of Reactive Oxygen Formation in Rat Liver
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    Chapter 36 Oxidative Stress during Hypoxia in Isolated-Perfused Rat Heart
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    Chapter 37 Alteration of Growth Rate and Fibronectin by Imbalances in Superoxide Dismutase and Glutathione Peroxidase Activity
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    Chapter 38 The Antidotal Activity of the Thiol Drug Diethyldithiocarbamate Against N-Acetyl-p-Benzoquinone Imine in Isolated Hepatocytes
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    Chapter 39 Two Classes of Azo Dye Reductase Activity Associated with Rat Liver Microsomal Cytochrome P-450
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    Chapter 40 Expression of a cDNA Encoding Rat Liver DT-Diaphorase in Escherichia Coli
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    Chapter 41 Suicidal Inactivation of Cytochrome P-450 by Halothane and Carbon Tetrachloride
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    Chapter 42 Structure-Activity Relationships of Acrylate Esters: Reactivity Towards Glutathione and Hydrolysis by Carboxylesterase in Vitro
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    Chapter 43 Glutathione Conjugates of Hydralazine Formed in Theperoxidase/Hydrogen Peroxide/Glutathione System
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    Chapter 44 Contribution of 3,4-Dichlorophenylhydroxylamine in Propanil-Induced Hemolytic Anemia
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    Chapter 45 A Reduction in Mixed Function Oxidases and in Tumor Promoting Effects of Ethanol in a NDEA-Initiated Hepatocarcinogenesis Model
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    Chapter 46 Selective Inducers of the Coh-Locus Enhance the Metabolisms of Coumarin- and of Quinoline-Derivatives but Not That of Naphthalenes
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    Chapter 47 Primaquine-Induced Oxidative Stress in Isolated Hepatocytes as a Result of Reductive Activation
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    Chapter 48 Nitroprusside: A Potpourri of Biologically Reactive Intermediates
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    Chapter 49 Denitrosation of N -Nitrosodimethylamine in the Rat in Vivo
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    Chapter 50 Effect of Phenol and Catechol on the Kinetics of Human Myeloperoxidase-Dependent Hydroquinone Metabolism
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    Chapter 51 Activation of 1-Hydroxymethylpyrene to an Electrophilic and Mutagenic Metabolite by Rat Hepatic Sulfotransferase Activity
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    Chapter 52 Bioactivation of 2,6-di-tert-butyl-4-methyl phenol (BHT) and hydroxylated analogues to toxic quinoid metabolites.
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    Chapter 53 Further Evidence for the Role of Myeloperoxidase in the Activation of Benzo[A]Pyrene-7,8-Dihydrodiol by Polymorpho-Nuclear Leukocytesm
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    Chapter 54 Quinones and their Glutathione Conjugates as Irreversible Inhibitors of Glutathione S-Transferases
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    Chapter 55 Cytochrome P450 IA2 Activity in Man Measured by Caffeine Metabolism: Effect of Smoking, Broccoli and Exercise
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    Chapter 56 Tissue Difference in Expression of Cytochrome P-450 between Liver and Lung of Syrian Golden Hamsters Treated with 3- Methylcholanthrene
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    Chapter 57 Role of calcium in toxic and programmed cell death.
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    Chapter 58 Molecular Mechanisms of y -Diketone Neuropathy
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    Chapter 59 Microtubule Assembly is Altered Following Covalent Modification by the n -Hexane Metabolite 2,5-Hexanedione
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    Chapter 60 The Role of Hepatic Metabolites of Benzene in Bone Marrow Peroxidase-Mediated Myelo- and Genotoxicity
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    Chapter 61 Glutathione Conjugation as a Mechanism of Targeting Latent Quinones to the Kidney
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    Chapter 62 Hepatic Bioactivation of 4-Vinylcyclohexene to Ovotoxic Epoxides
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    Chapter 63 Testicular Metabolism and Toxicity of Halogenated Propanes
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    Chapter 64 Lung Vascular Injury from Monocrotaline Pyrrole, a Putative Hepatic Metabolite
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    Chapter 65 Reactive Oxygen Species in the Progression of CCl 4 -Induced Liver Injury
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    Chapter 66 Parenchymal and Nonparenchymal Cell Interactions in Hepatotoxicity
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    Chapter 67 Signal Paths and Regulation of Superoxide, Eicosanoid and Cytokine Formation in Macrophages of Rat Liver
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    Chapter 68 Reactive Metabolites from N-Nitrosamines
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    Chapter 69 Bisfuranoid Mycotoxins: Their Genotoxicity and Carcinogenicity
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    Chapter 70 Covalent Bonding of Bay-Region Diol Epoxides to Nucleic Acids
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    Chapter 71 Electrophilic Sulfuric Acid Ester Metabolites of Hydroxy-Methyl Aromatic Hydrocarbons as Precursors of Hepatic Benzylic DNA Adducts in Vivo
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    Chapter 72 Heterocyclic Amines: New Mutagens and Carcinogenes in Cooked Foods
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    Chapter 73 Acetaminophen and Protein Thiol Modification
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    Chapter 74 Formation and Reactivity of a Quinone Methide in Biological Systems
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    Chapter 75 Mechanisms for Pyrrolizidine Alkaloid Activation and Detoxification
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    Chapter 76 Sulfur Conjugates as Putative Pneumotoxic Metabolites of the Pyrrolizidine Alkaloid, Monocrotaline
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    Chapter 77 The Metabolism of Benzene to Muconic Acid, a Potential Biological Marker of Benzene Exposure
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    Chapter 78 Lessons on the second cancers resulting from cancer chemotherapy.
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    Chapter 79 Genetic polymorphism of drug metabolism in humans.
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    Chapter 80 Human Health Risk Assessment and Biological Reactive Intermediates: Hemoglobin Binding
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    Chapter 81 Quantitating the Production of Biological Reactive Intermediates in Target Tissues: Example, Dichloromethane
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    Chapter 82 Trapping of Reactive Intermediates by Incorporation of 14 C-Sodium Cyanide during Microsomal Oxidation
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    Chapter 83 Multiple Bioactivation of Chloroform: A Comparison Between Man and Experimental Animals
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    Chapter 84 CCl 4 -Induced Cytochrome P-450 Loss and Lipid Peroxidation in Rat Liver Slices
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    Chapter 85 Alteration of Benzo(A)Pyrene-DNA Adduct Formation by Rats Exposed to Simple Mixtures
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    Chapter 86 Comparison of the Toxicity of Naphthalene and Naphthalene-1,2-Dihydrodiol (DIOL)
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    Chapter 87 Selective Binding of Acetaminophen (APAP) to Liver Proteins in Mice and Men
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    Chapter 88 Post-Treatment Protection with Piperonyl Butoxide Against Acetaminophen Hepatotoxicity is Associated with Changes in Selective but Not Total Covalent Binding
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    Chapter 89 Covalent Binding of a Halothane Metabolite and Neoantigen Production in Guinea Pig Liver Slices
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    Chapter 90 Extensive Alteration of Genomic DNA and Rise in Nuclear Ca 2+ in Vivo Early after Hepatotoxic Acetaminophen Overdose in Mice
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    Chapter 91 The Possible Role of Glutathione on the Hepatotoxic Effect of Papaverine Hydrochloride in Vitro
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    Chapter 92 In Vivo and in Vitro Evidence for in Situ Activation and Selective Covalent Binding of Acetaminophen (APAP) in Mouse Kidney
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    Chapter 93 Metabolism of Dichlorobenzenes in Organ Cultured Liver Slices
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    Chapter 94 Inhibition of Protein Synthesis and Secretion by Volatile Anesthetics in Guinea Pig Liver Slices
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    Chapter 95 Dichlorobenzene Hepatotoxicity Strain Differences and Structure Activity Relationships
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    Chapter 96 The Use of 19 F NMR in the Study of Protein Alkylation by Fluorinated Reactive Intermediates
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    Chapter 97 S-Ethylthiotrifluoroacetate Enhancement of the Immune Response to Halothane in the Guinea Pig
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    Chapter 98 Bone Marrow DNA Adducts and Bone Marrow Cellularity Following Treatment with Benzene Metabolites in Vivo
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    Chapter 99 The Role of γ-Glutamyl Transpeptidase in Hydroquinone-Glutathione Conjugate Mediated Nephrotoxicity
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    Chapter 100 Cytochrome P450IIE1 Metabolism of Pyridines: Evidence for Production of a Reactive Intermediate which Exhibits Redox-Cycling Activity and Causes DNA Damage
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    Chapter 101 Morphological Cell Transformation and DNA Adduction by Benz(J)Aceanthrylene and its Presumptive Reactive Metabolites in C3H10T1/2CL8 Cells
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    Chapter 102 Covalent Binding of Oxidative Biotransformation Reactive Intermediates to Protein Influences Halothane-Associated Hepatotoxicity in Guinea Pigs
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    Chapter 103 The Nephrotoxicity of 2,5-Dichloro-3-(Glutathion-S-YL)-1,4-Benzo-Quinone, and 2,5,6-Trichloro-3-(Glutathion-S-YL)-1,4-Benzoquinone is Potentiated by Ascorbic Acid and AT-125
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    Chapter 104 Generation of Free Radicals Results in Increased Rates of Protein Degradation in Human Erythrocytes
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    Chapter 105 Free Radicals Generated in Ethanol Metabolism May Be Responsible for Tumor Promoting Effects of Ethanol
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    Chapter 106 Composition of Hepatic Lipids after Ethanol, Cod Liver Oil and Vitamin E Feeding in Rats
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    Chapter 107 Dietary Polyunsaturated Fatty Acid Promote Peroxidation and its Possible Role in the Promotion of Cancer
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    Chapter 108 Chiral Epoxides, their Enantioselective Reactivity Towards Nucleic Acids, and a First Outline of a Quantum Chemical Structure-Reactivity Calculation
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    Chapter 109 Comparison of 8-hydroxydeoxyguanosine and 5-hydroxymethyluracil as products of oxidative DNA damage.
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    Chapter 110 Modulation of Aortic Smooth Muscle Cell Prolifertion by Dinitrotoluene
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    Chapter 111 Reactive Potential of Diethylstilbestrol Reactive Metabolites Towards Cellular Nuclear Proteins: Implications for Estrogen*Induced Carcinogenesis
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    Chapter 112 Biochemical and Morphologic Response of Nasal Epithelia to Hyperoxia
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    Chapter 113 Membrane Stabilization as a Fundamental Event in the Mechanism of Chemoprotection Against Chemical Intoxication
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    Chapter 114 Biochemical Effects and Toxicity of Mitoxantrone in Cultured Heart Cells
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    Chapter 115 Evidence for the Induction of an Oxidative Stress in Rat Hepatic Mitochondria by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD)
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    Chapter 116 Antioxidation Potential of Indole Compounds — Structure Activity Studies
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    Chapter 117 Measurement of Styrene-Oxide Cysteine Adducts in Hemoglobin by Selective Catalytic Reduction
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    Chapter 118 Studies on Biochemical Determinants of Quinone-Induced Toxicity in Primary Murine Bone Marrow Stromal Cells
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    Chapter 119 Selective Alteration of Cytokeratin Intermediate Filament by Cyclosporine A is a Lethal Toxicity in PTK2 Cell Cultures
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    Chapter 120 Rat Hepatic DNA Damage Induced by 1,2,3-Trichloropropane
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    Chapter 121 Oxidation of Reduced Porphyrins by the Mitochondrial Electron Transport Chain: Stimulation by Iron and Potential Role of Reactive Oxygen Species
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    Chapter 122 Future Research Needs for the Application of Mechanistic Data to Risk Assessment
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Title
Biological Reactive Intermediates IV
Published by
Springer New York, March 2013
DOI 10.1007/978-1-4684-5877-0
ISBNs
978-1-4684-5879-4, 978-1-4684-5877-0
Editors

Witmer, Charlotte M., Snyder, Robert R., Jollow, David J., Kalf, George F., Kocsis, James J., Sipes, I. Glenn

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Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 50%
Unknown 2 50%
Readers by discipline Count As %
Sports and Recreations 1 25%
Medicine and Dentistry 1 25%
Unknown 2 50%