| Title |
Microevolution and independent incursions as main forces shaping H5 Hemagglutinin diversity during a H5N8/H5N5 highly pathogenic avian influenza outbreak in Czech Republic in 2017
|
|---|---|
| Published in |
Archives of Virology, April 2018
|
| DOI | 10.1007/s00705-018-3833-7 |
| Pubmed ID | |
| Authors |
Alexander Nagy, Ádám Dán, Lenka Černíková, Eliška Vitásková, Vlastimil Křivda, Jitka Horníčková, Roman Masopust, Kamil Sedlák |
| Abstract |
Here, we present a comprehensive analysis of the H5N8/H5N5 highly pathogenic avian influenza (HPAI) virus strains detected in the Czech Republic during an outbreak in 2017. Network analysis of the H5 Hemagglutinin (HA) from 99% of the outbreak localities suggested that the diversity of the Czech H5N8/H5N5 viruses was influenced by two basic forces: local microevolution and independent incursions. The geographical occurrence of the central node H5 HA sequences revealed three eco-regions, which apparently played an important role in the origin and further spread of the local H5N8/HPAI variants across the country. A plausible explanation for the observed pattern of diversity is also provided. |
Mendeley readers
The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 29% |
| Student > Ph. D. Student | 1 | 14% |
| Unknown | 4 | 57% |
| Readers by discipline | Count | As % |
|---|---|---|
| Veterinary Science and Veterinary Medicine | 1 | 14% |
| Nursing and Health Professions | 1 | 14% |
| Agricultural and Biological Sciences | 1 | 14% |
| Unknown | 4 | 57% |