| Title |
Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases
|
|---|---|
| Published in |
Acta Neuropathologica, July 2007
|
| DOI | 10.1007/s00401-007-0261-2 |
| Pubmed ID | |
| Authors |
Hanae Nakashima-Yasuda, Kunihiro Uryu, John Robinson, Sharon X. Xie, Howard Hurtig, John E. Duda, Steven E. Arnold, Andrew Siderowf, Murray Grossman, James B. Leverenz, Randy Woltjer, Oscar L. Lopez, Ronald Hamilton, Debby W. Tsuang, Douglas Galasko, Eliezer Masliah, Jeffrey Kaye, Christopher M. Clark, Thomas J. Montine, Virginia M. -Y. Lee, John Q. Trojanowski |
| Abstract |
Here, we investigated if TAR-DNA-binding protein-43 (TDP-43), the disease protein in frontotemporal lobar degeneration and ubiquitin inclusions with or without motor neuron disease as well as amyotrophic lateral sclerosis, also formed inclusions in Lewy body (LB) disorders including Parkinson's disease (PD) without or with dementia (PDD), and dementia with LBs (DLB) alone or in association with Alzheimer's disease (AD). Immunohistochemical analyses of TDP-43 in clinically well characterized and pathologically confirmed cases of DLB + AD, PD and PDD demonstrated TDP-43 pathology in the following percentage of cases: DLB + AD = 25/80 (31.3%); PD = 5/69 (7.2%); PDD = 4/21 (19%), while DLB and normal controls exhibited no (0/10, 0%) and one cases (1/33, 3%) presenting TDP-43 pathology, respectively. Significant differences in the prevalence of TDP-43 lesions were noted between disease versus normal brains (P < 0.001) as well as demented versus non-demented brains (P < 0.001). Statistical analyses revealed a positive relationship between TDP-43 lesions and several clinical and pathological parameters in these disorders suggesting the TDP-43 pathology may have co-morbid effects in LB diseases. This study expands the concept of TDP-43 proteinopathies by implicating TDP-43 lesions in mechanisms of neurodegeneration in LB disorders. |
Mendeley readers
The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 2% |
| United Kingdom | 2 | 1% |
| United States | 2 | 1% |
| Belgium | 1 | <1% |
| Philippines | 1 | <1% |
| Unknown | 190 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 27% |
| Researcher | 35 | 18% |
| Student > Doctoral Student | 16 | 8% |
| Student > Bachelor | 15 | 8% |
| Student > Master | 11 | 6% |
| Other | 35 | 18% |
| Unknown | 34 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 41 | 21% |
| Neuroscience | 41 | 21% |
| Biochemistry, Genetics and Molecular Biology | 35 | 18% |
| Medicine and Dentistry | 29 | 15% |
| Psychology | 4 | 2% |
| Other | 10 | 5% |
| Unknown | 39 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2015.
All research outputs
#5,672,186
of 22,789,566 outputs
Outputs from Acta Neuropathologica
#1,203
of 2,366 outputs
Outputs of similar age
#19,754
of 67,117 outputs
Outputs of similar age from Acta Neuropathologica
#5
of 17 outputs
Altmetric has tracked 22,789,566 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,366 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 67,117 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.