| Title |
Ins1Cre knock-in mice for beta cell-specific gene recombination
|
|---|---|
| Published in |
Diabetologia, December 2014
|
| DOI | 10.1007/s00125-014-3468-5 |
| Pubmed ID | |
| Authors |
Bernard Thorens, David Tarussio, Miguel Angel Maestro, Meritxell Rovira, Eija Heikkilä, Jorge Ferrer |
| Abstract |
Pancreatic beta cells play a central role in the control of glucose homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues. Understanding the molecular mechanisms that control beta cell function and plasticity has critical implications for the pathophysiology and therapy of major forms of diabetes. Selective gene inactivation in pancreatic beta cells, using the Cre-lox system, is a powerful approach to assess the role of particular genes in beta cells and their impact on whole body glucose homeostasis. Several Cre recombinase (Cre) deleter mice have been established to allow inactivation of genes in beta cells, but many show non-specific recombination in other cell types, often in the brain. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 4 | 50% |
| United States | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 50% |
| Members of the public | 4 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 141 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 44 | 31% |
| Researcher | 32 | 22% |
| Student > Bachelor | 13 | 9% |
| Student > Master | 12 | 8% |
| Student > Postgraduate | 6 | 4% |
| Other | 16 | 11% |
| Unknown | 20 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 51 | 36% |
| Agricultural and Biological Sciences | 38 | 27% |
| Medicine and Dentistry | 14 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Neuroscience | 3 | 2% |
| Other | 8 | 6% |
| Unknown | 23 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2021.
All research outputs
#6,962,179
of 25,368,786 outputs
Outputs from Diabetologia
#2,759
of 5,341 outputs
Outputs of similar age
#88,518
of 368,205 outputs
Outputs of similar age from Diabetologia
#24
of 40 outputs
Altmetric has tracked 25,368,786 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 5,341 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
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We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.