| Title |
Role of BK human polyomavirus in cancer
|
|---|---|
| Published in |
Infectious Agents and Cancer, April 2018
|
| DOI | 10.1186/s13027-018-0182-9 |
| Pubmed ID | |
| Authors |
Jorge Levican, Mónica Acevedo, Oscar León, Aldo Gaggero, Francisco Aguayo |
| Abstract |
Human polyomaviruses (HPyV), which are small DNA viruses classified into the polyomaviridae family, are widely distributed in human populations. Thirteen distinct HPyVs have been described to date. Some of these viruses have been found in human tumors, suggesting an etiological relationship with cancer. In particular, convincing evidence of an oncogenic role has emerged for a specific HPyV, the Merkel cell polyomavirus (MCPyV). This HPyV has been linked to rare skin cancer, Merkel cell carcinoma (MCC). This finding may be just the tip of the iceberg, as HPyV infections are ubiquitous in humans. Many authors have conjectured that additional associations between HPyV infections and neoplastic diseases will likely be discovered. In 2012, the International Agency for Research on Cancer (IARC) evaluated the carcinogenicity of the BK virus (BKPyV), reporting that BKPyV is "possibly carcinogenic to humans." This review explores the BKPyV infection from a historical point of view, including biological aspects related to viral entry, tropism, epidemiology and mechanisms potentially involved in BKPyV-mediated human carcinogenesis. In order to clarify the role of this virus in human cancer, more epidemiological and basic research is strongly warranted. |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 51 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 14% |
| Student > Master | 7 | 14% |
| Other | 4 | 8% |
| Student > Postgraduate | 4 | 8% |
| Student > Ph. D. Student | 4 | 8% |
| Other | 8 | 16% |
| Unknown | 17 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 24% |
| Medicine and Dentistry | 9 | 18% |
| Immunology and Microbiology | 5 | 10% |
| Agricultural and Biological Sciences | 3 | 6% |
| Chemical Engineering | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 20 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2018.
All research outputs
#7,553,524
of 23,041,514 outputs
Outputs from Infectious Agents and Cancer
#120
of 523 outputs
Outputs of similar age
#132,085
of 329,678 outputs
Outputs of similar age from Infectious Agents and Cancer
#4
of 6 outputs
Altmetric has tracked 23,041,514 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 523 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,678 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.