| Title |
Primary function analysis of human mental retardation related gene CRBN
|
|---|---|
| Published in |
Molecular Biology Reports, March 2007
|
| DOI | 10.1007/s11033-007-9077-3 |
| Pubmed ID | |
| Authors |
Wang Xin, Ni Xiaohua, Chen Peilin, Chen Xin, Sun Yaqiong, Wu Qihan |
| Abstract |
The mutation of human cereblon gene (CRBN) is revealed to be related with mild mental retardation. Since the molecular characteristics of CRBN have not been well presented, we investigated the general properties of CRBN. We analyzed its gene structure and protein homologues. The CRBN protein might belong to a family of adenosine triphosphate (ATP)-dependent Lon protease. We also found that CRBN was widely expressed in different tissues, and the expression level in testis is significantly higher than other tissues. This may suggested it could play some important roles in several other tissues besides brain. Transient transfection experiment in AD 293 cell lines suggested that both CRBN and CRBN mutant (nucleotide position 1,274(C > T)) are located in the whole cells. This may suggest new functions of CRBN in cell nucleolus besides its mitochondria protease activity in cytoplasm. |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| United States | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 40 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 21% |
| Researcher | 7 | 16% |
| Student > Bachelor | 6 | 14% |
| Student > Master | 4 | 9% |
| Student > Doctoral Student | 3 | 7% |
| Other | 7 | 16% |
| Unknown | 7 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 33% |
| Biochemistry, Genetics and Molecular Biology | 10 | 23% |
| Medicine and Dentistry | 4 | 9% |
| Neuroscience | 4 | 9% |
| Psychology | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 7 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2023.
All research outputs
#4,791,680
of 23,151,189 outputs
Outputs from Molecular Biology Reports
#216
of 2,972 outputs
Outputs of similar age
#14,732
of 77,439 outputs
Outputs of similar age from Molecular Biology Reports
#1
of 3 outputs
Altmetric has tracked 23,151,189 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,972 research outputs from this source. They receive a mean Attention Score of 2.2. This one has done particularly well, scoring higher than 91% of its peers.
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We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them