| Title |
The DHHC domain: A new highly conserved cysteine-rich motif
|
|---|---|
| Published in |
Molecular and Cellular Biochemistry, May 1999
|
| DOI | 10.1023/a:1006932522197 |
| Pubmed ID | |
| Authors |
T. Putilina, P. Wong, S. Gentleman |
| Abstract |
A unique clone from a human pancreatic cDNA library was isolated and sequenced. Examination of the deduced polypeptide sequence of the clone showed a new form of cysteine-rich domain that included a region with the form of a Cys4 zinc-finger-like metal binding site followed by a complex Cys-His region. Searches of the Swiss-Protein data bank found a similar 48-residue domain in fifteen open reading frames deduced from A. thaliana, C. elegans, S. cerevisiae and S. pombe genomic sequences. The high degree of conservation of this domain (13 absolutely conserved and 17 highly conserved positions) suggests that it has an important function in the cell, possibly related to protein-protein or protein-DNA interactions. The gene recognized by the clone is is localized to human chromosome 16, and is conserved in vertebrates. The 2 Kb message is expressed in various human fetal and adult tissues. An antibody made to a peptide sequence of the deduced protein showed reactivity in immunoblots of monkey lung and retinal subcellular fractions and immunohistochemically in late fetal mouse tissues and a limited number of adult mouse tissues, including pancreatic islets, Leydig cells of the testis, and the plexiform layers of the retina. |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 5% |
| Spain | 1 | 2% |
| Argentina | 1 | 2% |
| Unknown | 54 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 29% |
| Researcher | 10 | 17% |
| Student > Master | 10 | 17% |
| Student > Bachelor | 9 | 15% |
| Student > Doctoral Student | 2 | 3% |
| Other | 6 | 10% |
| Unknown | 5 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 41% |
| Biochemistry, Genetics and Molecular Biology | 16 | 27% |
| Medicine and Dentistry | 3 | 5% |
| Neuroscience | 3 | 5% |
| Chemistry | 2 | 3% |
| Other | 3 | 5% |
| Unknown | 8 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2019.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from Molecular and Cellular Biochemistry
#481
of 2,447 outputs
Outputs of similar age
#11,894
of 36,586 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#2
of 5 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,447 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 51% of its peers.
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We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.