Title |
DSB proteins and bacterial pathogenicity
|
---|---|
Published in |
Nature Reviews Microbiology, February 2009
|
DOI | 10.1038/nrmicro2087 |
Pubmed ID | |
Authors |
Begoña Heras, Stephen R. Shouldice, Makrina Totsika, Martin J. Scanlon, Mark A. Schembri, Jennifer L. Martin |
Abstract |
If DNA is the information of life, then proteins are the machines of life--but they must be assembled and correctly folded to function. A key step in the protein-folding pathway is the introduction of disulphide bonds between cysteine residues in a process called oxidative protein folding. Many bacteria use an oxidative protein-folding machinery to assemble proteins that are essential for cell integrity and to produce virulence factors. Although our current knowledge of this machinery stems largely from Escherichia coli K-12, this view must now be adjusted to encompass the wider range of disulphide catalytic systems present in bacteria. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 3 | 1% |
United States | 3 | 1% |
India | 1 | <1% |
Chile | 1 | <1% |
Denmark | 1 | <1% |
Poland | 1 | <1% |
Unknown | 204 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 59 | 28% |
Researcher | 40 | 19% |
Student > Master | 25 | 12% |
Student > Bachelor | 16 | 7% |
Student > Postgraduate | 16 | 7% |
Other | 29 | 14% |
Unknown | 29 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 88 | 41% |
Biochemistry, Genetics and Molecular Biology | 32 | 15% |
Chemistry | 21 | 10% |
Immunology and Microbiology | 18 | 8% |
Medicine and Dentistry | 17 | 8% |
Other | 9 | 4% |
Unknown | 29 | 14% |