| Title |
The genes for the human VPS10 domain-containing receptors are large and contain many small exons
|
|---|---|
| Published in |
Human Genetics, May 2001
|
| DOI | 10.1007/s004390100504 |
| Pubmed ID | |
| Authors |
Wolfgang Hampe, Meriem Rezgaoui, Irm Hermans-Borgmeyer, Chica H. Schaller |
| Abstract |
The two human proteins with a VPS10 domain, SorLA and sortilin, both bind neuropeptides. Searching for other VPS10-domain proteins in the database revealed three new putative human neuropeptide receptors. The new receptors were designated SorCS1, SorCS2 and SorCS3, due to their identical domain composition, which, except for the N-terminal VPS10 domain, differs from that of SorLA and sortilin. Using the databases of the human genome project we elucidated the exon-intron structures of the human VPS10-receptor genes. They contain many short exons, separated by introns, several of which extend over more than 50 kb. The three SorCS genes encompass more than 500 kb of genomic DNA and therefore represent some of the largest known human genes. All these genes map to chromosomal localisations of known genetic diseases, many of them neurological disorders, corresponding to the strong expression of these receptors in the brain. CpG islands are located in the first exon of each of the VPS10-receptor genes and might be involved in developmental or tissue-specific regulation of gene expression. |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 2 | 3% |
| United Kingdom | 1 | 2% |
| United States | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 53 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 24% |
| Student > Master | 10 | 17% |
| Student > Bachelor | 7 | 12% |
| Student > Ph. D. Student | 7 | 12% |
| Other | 3 | 5% |
| Other | 8 | 14% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 26% |
| Agricultural and Biological Sciences | 14 | 24% |
| Medicine and Dentistry | 7 | 12% |
| Neuroscience | 7 | 12% |
| Chemistry | 2 | 3% |
| Other | 4 | 7% |
| Unknown | 9 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2017.
All research outputs
#3,272,573
of 22,790,780 outputs
Outputs from Human Genetics
#294
of 2,953 outputs
Outputs of similar age
#3,503
of 40,132 outputs
Outputs of similar age from Human Genetics
#1
of 11 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,953 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 40,132 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.