| Title |
Giant cell tumour of bone: morphological, biological and histogenetical aspects
|
|---|---|
| Published in |
International Orthopaedics, September 2006
|
| DOI | 10.1007/s00264-006-0215-7 |
| Pubmed ID | |
| Authors |
Mathias Werner |
| Abstract |
The giant cell tumour of bone (GCT) is a locally aggressive intraosseous neoplasm of obscure biological behaviour. Although well defined in clinical, radiological and histological terms, detailed information on its biological development is still relatively incomplete. The tumoral tissue consists of three cell types--the neoplastic giant cell tumour stromal cells (GCTSC), representing the proliferative fraction, secondarily recruited mononuclear histiocytic cells (MNHC) and multinuclear giant cells (MNGC). These cellular components interact together with factors that have a role in regulating osteoclast function in normal bone tissue (e.g. RANK, RANKL, OPG, M-CSF). Recent publications suggest that the neoplastic stromal cells express differentiation features of mesenchymal stem cells. Further research of the pathogenesis of GCT as well as the complex interactions of its cellular populations may provide the knowledge necessary for developing approaches for a biological-based therapy of this neoplasm. |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 109 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 13% |
| Other | 13 | 12% |
| Student > Master | 10 | 9% |
| Student > Bachelor | 9 | 8% |
| Student > Ph. D. Student | 9 | 8% |
| Other | 25 | 23% |
| Unknown | 30 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 41% |
| Biochemistry, Genetics and Molecular Biology | 9 | 8% |
| Agricultural and Biological Sciences | 7 | 6% |
| Nursing and Health Professions | 2 | 2% |
| Neuroscience | 2 | 2% |
| Other | 11 | 10% |
| Unknown | 34 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2023.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from International Orthopaedics
#416
of 1,427 outputs
Outputs of similar age
#23,403
of 67,220 outputs
Outputs of similar age from International Orthopaedics
#6
of 13 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,427 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 50% of its peers.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.