Chapter title |
Dry Age-Related Macular Degeneration Pharmacology
|
---|---|
Chapter number | 36 |
Book title |
Pharmacologic Therapy of Ocular Disease
|
Published in |
Handbook of experimental pharmacology, January 2016
|
DOI | 10.1007/164_2016_36 |
Pubmed ID | |
Book ISBNs |
978-3-31-958288-7, 978-3-31-958290-0
|
Authors |
Charles B. Wright, Jayakrishna Ambati, Wright, Charles B., Ambati, Jayakrishna |
Abstract |
Age-related macular degeneration (AMD), the most common form of irreversible blindness in the industrially developed world, can present years before a patient begins to lose vision. For most of these patients, AMD never progresses past its early stages to the advanced forms that are principally responsible for the vast majority of vision loss. Advanced AMD can manifest as either an advanced avascular form known as geographic atrophy (GA) marked by regional retinal pigment epithelium (RPE) cell death or as an advanced form known as neovascular AMD marked by the intrusion of fragile new blood vessels into the normally avascular retina. Physicians have several therapeutic interventions available to combat neovascular AMD, but GA has no approved effective therapies as of yet. In this chapter, we will discuss the current strategies for limiting dry AMD in patients. We will also discuss previous attempts at pharmacological intervention that were tested in a clinical setting and consider reasons why these putative therapeutics did not perform successfully in large-scale trials. Despite the number of unsuccessful past trials, new pharmacological interventions may succeed. These future therapies may aid millions of AMD patients worldwide. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 9 | 18% |
Student > Ph. D. Student | 6 | 12% |
Student > Master | 4 | 8% |
Researcher | 4 | 8% |
Other | 2 | 4% |
Other | 2 | 4% |
Unknown | 23 | 46% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 8 | 16% |
Biochemistry, Genetics and Molecular Biology | 7 | 14% |
Neuroscience | 3 | 6% |
Psychology | 2 | 4% |
Immunology and Microbiology | 1 | 2% |
Other | 3 | 6% |
Unknown | 26 | 52% |