| Title |
The oncofetal Thomsen–Friedenreich carbohydrate antigen in cancer progression
|
|---|---|
| Published in |
Glycoconjugate Journal, April 2007
|
| DOI | 10.1007/s10719-007-9034-3 |
| Pubmed ID | |
| Authors |
Lu-Gang Yu |
| Abstract |
The oncofetal Thomsen-Friedenreich carbohydrate antigen (Galbeta1-3GalNAcalpha1-Ser/Thr TF or T antigen) is a pan-carcinoma antigen highly expressed by about 90% of all human carcinomas. Its broad expression and high specificity in cancer have attracted many investigations into its potential use in cancer diagnosis and immunotherapy. Over the past few years increasing evidence suggests that the increased TF occurrence in cancer cells may be functionally important in cancer progression by allowing increased interaction/communication of the cells with endogenous carbohydrate-binding proteins (lectins), particularly the members of the galactoside-binding galectin family. This review focuses on the recent progress in understanding of the regulation and functional significance of increased TF occurrence in cancer progression and metastasis. |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 2 | 2% |
| Unknown | 90 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 21% |
| Student > Ph. D. Student | 17 | 18% |
| Student > Master | 14 | 15% |
| Student > Bachelor | 9 | 10% |
| Student > Postgraduate | 4 | 4% |
| Other | 13 | 14% |
| Unknown | 16 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 32% |
| Biochemistry, Genetics and Molecular Biology | 19 | 21% |
| Chemistry | 12 | 13% |
| Medicine and Dentistry | 4 | 4% |
| Nursing and Health Professions | 1 | 1% |
| Other | 7 | 8% |
| Unknown | 20 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 May 2016.
All research outputs
#3,799,086
of 25,374,917 outputs
Outputs from Glycoconjugate Journal
#38
of 929 outputs
Outputs of similar age
#9,880
of 86,819 outputs
Outputs of similar age from Glycoconjugate Journal
#1
of 4 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 929 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 86,819 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them