| Title |
Resolution of anaphase bridges in cancer cells
|
|---|---|
| Published in |
Chromosoma, May 2004
|
| DOI | 10.1007/s00412-004-0284-6 |
| Pubmed ID | |
| Authors |
Diane R. Hoffelder, Li Luo, Nancy A. Burke, Simon C. Watkins, Susanne M. Gollin, William S. Saunders |
| Abstract |
Chromosomal instability is a key step in the generation of the cancer cell karyotype. An indicator of unstable chromosomes is the presence of chromatin bridges during anaphase. We examined in detail the fate of anaphase bridges in cultured oral squamous cell carcinoma cells in real-time. Surprisingly, chromosomes in bridges typically resolve by breaking into multiple fragments. Often these fragments give rise to micronuclei (MN) at the end of mitosis. The formation of MN is shown to have important consequences for the cell. We found that MN have incomplete nuclear pore complex (NPC) formation and nuclear import defects and the chromatin within has greatly reduced transcriptional activity. Thus, a major consequence of the presence of anaphase bridges is the regular sequestration of chromatin into genetically inert MN. This represents another source of ongoing genetic instability in cancer cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 191 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 1% |
| United States | 2 | 1% |
| Netherlands | 1 | <1% |
| Denmark | 1 | <1% |
| Brazil | 1 | <1% |
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 182 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 47 | 25% |
| Researcher | 25 | 13% |
| Student > Bachelor | 24 | 13% |
| Student > Master | 23 | 12% |
| Student > Doctoral Student | 16 | 8% |
| Other | 22 | 12% |
| Unknown | 34 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 65 | 34% |
| Biochemistry, Genetics and Molecular Biology | 61 | 32% |
| Medicine and Dentistry | 8 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Chemistry | 4 | 2% |
| Other | 9 | 5% |
| Unknown | 39 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2013.
All research outputs
#7,542,740
of 23,012,811 outputs
Outputs from Chromosoma
#183
of 760 outputs
Outputs of similar age
#18,834
of 58,284 outputs
Outputs of similar age from Chromosoma
#2
of 6 outputs
Altmetric has tracked 23,012,811 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 760 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 58,284 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.