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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Prospective Analyses of Cytokine Mediation of Sleep and Survival in the Context of Advanced Cancer
|
|---|---|
| Published in |
Psychosomatic Medicine, June 2018
|
| DOI | 10.1097/psy.0000000000000579 |
| Pubmed ID | |
| Authors |
Jennifer L. Steel, Lauren Terhorst, Kevin P. Collins, David A. Geller, Yoram Vodovotz, Juliana Kim, Andrew Krane, Michael Antoni, James W. Marsh, Lora E. Burke, Lisa H. Butterfield, Frank J. Penedo, Daniel J. Buysse, Allan Tsung |
| Abstract |
The aims of this study were to examine the potential association between sleep problems, symptom burden, and survival in advanced cancer patients. A prospective study of 294 patients with gastrointestinal cancer were administered questionnaires assessing sleep, depression, anxiety, stress, pain, fatigue, and health-related quality of life. Serum levels of cytokines including Interleukin (IL)-1α, IL-1β, Tumor Necrosis Factor-α, IL-10, IL-2, and IFNγ were measured to assess biological mediation between sleep and survival. Survival was measured as time from diagnosis to death. Fifty-nine percent of patients reported poor sleep quality, 53% reported poor sleep efficiency, 39% reported sleep latency greater than 30 minutes, and 45% reported sleeping <6 hours or >10 hours. We found a significant association between sleep duration and symptom burden. Shorter sleep duration was significantly associated with higher levels of fatigue (r=-0.169, p=0.01), pain (r=-0.302, p=0.01), anxiety (r=-0.182, p=0.01), depression (r=-0.172, p=0.003) and lower levels of quality of life (r=0.240, p=0.01). After adjustment for demographic, psychological, and disease-specific factors, short sleep duration was associated with reduced survival HR linear = 0.485, 95% CI=0.275-0.857] and there was also evidence for a quadratic pattern [HR quadratic =1.064, 95% CI=1.015-1.115] suggesting a curvilinear relationship between sleep duration and survival. Interleukin-2 was the only cytokine significantly related to survival [HR=1.01, p=0.003] and sleep duration [β=--30.11, p=-0.027]. When serum levels of IL-2 was added to the multivariable model, short and long sleep [β =-0.557, p=0.097; β=0.046, p=0.114] were no longer significantly related to survival, suggesting mediation by IL-2. Sleep duration was associated with symptom burden and poorer survival and IL-2 was found to mediate the association between sleep and survival. Screening and treatment of sleep problems in patients diagnosed with cancer is warranted. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 77 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 17% |
| Student > Ph. D. Student | 12 | 16% |
| Student > Doctoral Student | 5 | 6% |
| Student > Postgraduate | 4 | 5% |
| Student > Master | 4 | 5% |
| Other | 13 | 17% |
| Unknown | 26 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 17% |
| Psychology | 12 | 16% |
| Nursing and Health Professions | 6 | 8% |
| Neuroscience | 4 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 7 | 9% |
| Unknown | 33 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2018.
All research outputs
#17,292,294
of 25,382,440 outputs
Outputs from Psychosomatic Medicine
#1,978
of 2,498 outputs
Outputs of similar age
#221,357
of 342,877 outputs
Outputs of similar age from Psychosomatic Medicine
#17
of 25 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,498 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.6. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,877 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.