| Title |
Impairment of sensory-motor integration in patients affected by RLS
|
|---|---|
| Published in |
Journal of Neurology, July 2010
|
| DOI | 10.1007/s00415-010-5644-y |
| Pubmed ID | |
| Authors |
Vincenzo Rizzo, I. Aricò, G. Liotta, L. Ricciardi, C. Mastroeni, F. Morgante, R. Allegra, R. Condurso, P. Girlanda, R. Silvestri, A. Quartarone |
| Abstract |
Much evidence suggests that restless legs syndrome (RLS) is a disorder characterized by an unsuppressed response to sensory urges due to abnormalities in inhibitory pathways that specifically link sensory input and motor output. Therefore, in the present study, we tested sensory-motor integration in patients with RLS, measured by short latency afferent inhibition (SAI) and long latency afferent inhibition (LAI). SAI and LAI were determined using transcranial magnetic stimulation before and after 1 month of dopaminergic treatment in RLS patients. Ten naïve patients with idiopathic RLS and ten healthy age-matched controls were recruited. Patients with secondary causes for RLS (e.g. renal failure, anaemia, low iron and ferritin) were excluded, as well as those with other sleep disorders. Untreated RLS patients demonstrated deficient SAI in the human motor cortex, which proved revertible toward normal values after dopaminergic treatment. We demonstrated an alteration of sensory-motor integration, which is normalized by dopaminergic treatment, in patients affected by RLS. It is likely that the reduction of SAI might contribute significantly to the release of the involuntary movements and might account for the sensory urge typical of this condition. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 16% |
| Researcher | 8 | 16% |
| Student > Bachelor | 6 | 12% |
| Student > Doctoral Student | 2 | 4% |
| Other | 2 | 4% |
| Other | 9 | 18% |
| Unknown | 14 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 22% |
| Neuroscience | 10 | 20% |
| Agricultural and Biological Sciences | 7 | 14% |
| Nursing and Health Professions | 3 | 6% |
| Psychology | 2 | 4% |
| Other | 0 | 0% |
| Unknown | 16 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2020.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Journal of Neurology
#1,774
of 4,475 outputs
Outputs of similar age
#33,950
of 95,152 outputs
Outputs of similar age from Journal of Neurology
#6
of 23 outputs
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