Title |
The Immunobiology of Cancer Immunosurveillance and Immunoediting
|
---|---|
Published in |
Immunity, August 2004
|
DOI | 10.1016/j.immuni.2004.07.017 |
Pubmed ID | |
Authors |
Gavin P. Dunn, Lloyd J. Old, Robert D. Schreiber |
Abstract |
The last fifteen years have seen a reemergence of interest in cancer immunosurveillance and a broadening of this concept into one termed cancer immunoediting. The latter, supported by strong experimental data derived from murine tumor models and provocative correlative data obtained by studying human cancer, holds that the immune system not only protects the host against development of primary nonviral cancers but also sculpts tumor immunogenicity. Cancer immunoediting is a process consisting of three phases: elimination (i.e., cancer immunosurveillance), equilibrium, and escape. Herein, we summarize the data supporting the existence of each of the three cancer immunoediting phases. The full understanding of the immunobiology of cancer immunosurveillance and immunoediting will hopefully stimulate development of more effective immunotherapeutic approaches to control and/or eliminate human cancers. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 14 | <1% |
Germany | 5 | <1% |
France | 4 | <1% |
Denmark | 3 | <1% |
Spain | 3 | <1% |
United Kingdom | 3 | <1% |
Netherlands | 2 | <1% |
Austria | 2 | <1% |
Switzerland | 2 | <1% |
Other | 17 | <1% |
Unknown | 2142 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 391 | 18% |
Student > Master | 319 | 15% |
Student > Bachelor | 291 | 13% |
Researcher | 235 | 11% |
Student > Doctoral Student | 117 | 5% |
Other | 302 | 14% |
Unknown | 542 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 429 | 20% |
Medicine and Dentistry | 378 | 17% |
Biochemistry, Genetics and Molecular Biology | 340 | 15% |
Immunology and Microbiology | 219 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 67 | 3% |
Other | 178 | 8% |
Unknown | 586 | 27% |