| Title |
Kinesin motor proteins as targets for cancer therapy
|
|---|---|
| Published in |
Cancer and Metastasis Reviews, January 2009
|
| DOI | 10.1007/s10555-009-9185-8 |
| Pubmed ID | |
| Authors |
Dennis Huszar, Maria-Elena Theoclitou, Jeffrey Skolnik, Ronald Herbst |
| Abstract |
The process of mitosis is a validated point of intervention in cancer therapy and a variety of anti-mitotic drugs are successfully being used in the clinic. To date, all approved antimitotics target the spindle microtubules, thus interfering with spindle dynamics, leading to mitotic arrest and apoptosis. While effective, these drugs are also associated with a variety of side effects, including neurotoxicity. In recent years, mitotic kinesins have attracted significant attention in the search for novel, alternative mitotic drug targets. Due to their specific function in mitosis, targeting these proteins creates an opportunity for the development of more selective antimitotics with an improved side effect profile. In addition, kinesin inhibitors may overcome resistance to microtubule targeting drugs. Drug discovery efforts in this area have initially focused on the plus-end directed kinesin spindle protein (KSP) and a variety of compounds are currently undergoing clinical testing. |
Mendeley readers
The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Germany | 1 | <1% |
| Portugal | 1 | <1% |
| United Kingdom | 1 | <1% |
| France | 1 | <1% |
| Unknown | 143 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 24% |
| Researcher | 21 | 14% |
| Student > Master | 20 | 13% |
| Student > Bachelor | 16 | 11% |
| Student > Postgraduate | 7 | 5% |
| Other | 21 | 14% |
| Unknown | 28 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 53 | 36% |
| Biochemistry, Genetics and Molecular Biology | 15 | 10% |
| Chemistry | 14 | 9% |
| Medicine and Dentistry | 8 | 5% |
| Physics and Astronomy | 7 | 5% |
| Other | 22 | 15% |
| Unknown | 30 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2023.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Cancer and Metastasis Reviews
#286
of 807 outputs
Outputs of similar age
#49,504
of 170,414 outputs
Outputs of similar age from Cancer and Metastasis Reviews
#6
of 15 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 807 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,414 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.