| Title |
Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism
|
|---|---|
| Published in |
Journal of Neural Transmission, December 2004
|
| DOI | 10.1007/s00702-004-0232-x |
| Pubmed ID | |
| Authors |
D. Bönsch, B. Lenz, U. Reulbach, J. Kornhuber, S. Bleich |
| Abstract |
Higher plasma homocysteine concentrations can influence genomic DNA methylation in peripheral blood cells. In the present controlled study we observed a significant increase (10%) of genomic DNA methylation in patients with alcoholism (t = -3.16, df = 158, p = 0.002) which was significantly associated with their elevated homocysteine levels (multiple linear regression, p < 0.001). Since methylation of DNA is an important epigenetic factor in regulation of gene expression these findings may have important implications for a possible subsequent derangement of epigenetic control these patients. |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 57 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 23% |
| Student > Ph. D. Student | 10 | 18% |
| Student > Master | 7 | 12% |
| Student > Bachelor | 6 | 11% |
| Student > Doctoral Student | 3 | 5% |
| Other | 6 | 11% |
| Unknown | 12 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 26% |
| Medicine and Dentistry | 14 | 25% |
| Biochemistry, Genetics and Molecular Biology | 8 | 14% |
| Neuroscience | 4 | 7% |
| Psychology | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 12 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2021.
All research outputs
#4,697,128
of 22,790,780 outputs
Outputs from Journal of Neural Transmission
#425
of 1,764 outputs
Outputs of similar age
#16,864
of 140,535 outputs
Outputs of similar age from Journal of Neural Transmission
#5
of 13 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,764 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,535 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.