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Mendeley readers
Attention Score in Context
| Title |
MicroRNA Expression Profiles Associated with Mutational Status and Survival in Malignant Melanoma
|
|---|---|
| Published in |
Journal of Investigative Dermatology, April 2010
|
| DOI | 10.1038/jid.2010.63 |
| Pubmed ID | |
| Authors |
Stefano Caramuta, Suzanne Egyházi, Monica Rodolfo, Daniela Witten, Johan Hansson, Catharina Larsson, Weng-Onn Lui |
| Abstract |
Malignant cutaneous melanoma is a highly aggressive form of skin cancer. Despite improvements in early melanoma diagnosis, the 5-year survival rate remains low in advanced disease. Therefore, novel biomarkers are urgently needed to devise new means of detection and treatment. In this study, we aimed to improve our understanding of microRNA (miRNA) deregulation in melanoma development and their impact on patient survival. Global miRNA expression profiles of a set of melanoma lymph node metastases, melanoma cell lines, and melanocyte cultures were determined using Agilent array. Deregulated miRNAs were evaluated in relation with clinical characteristics, patient survival, and mutational status for BRAF and NRAS. Several miRNAs were differentially expressed between melanocytes and melanomas as well as melanoma cell lines. In melanomas, miR-193a, miR-338, and miR-565 were underexpressed in cases with a BRAF mutation. Furthermore, low expression of miR-191 and high expression of miR-193b were associated with poor melanoma-specific survival. In conclusion, our findings show miRNA dysregulation in malignant melanoma and its relation to established molecular backgrounds of BRAF and NRAS oncogenic mutations. The identification of an miRNA classifier for poor survival may lead to the development of miRNA detection as a complementary prognostic tool in clinical practice. |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| South Africa | 1 | <1% |
| Denmark | 1 | <1% |
| China | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 120 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 24% |
| Student > Ph. D. Student | 27 | 21% |
| Student > Master | 16 | 13% |
| Student > Bachelor | 11 | 9% |
| Other | 10 | 8% |
| Other | 14 | 11% |
| Unknown | 18 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 51 | 40% |
| Biochemistry, Genetics and Molecular Biology | 27 | 21% |
| Medicine and Dentistry | 14 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Computer Science | 3 | 2% |
| Other | 8 | 6% |
| Unknown | 21 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2021.
All research outputs
#3,907,044
of 26,017,215 outputs
Outputs from Journal of Investigative Dermatology
#1,242
of 9,171 outputs
Outputs of similar age
#15,290
of 106,884 outputs
Outputs of similar age from Journal of Investigative Dermatology
#8
of 35 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,171 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 106,884 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.