| Title |
Metabonomics and population studies: age-related amino acids excretion and inferring networks through the study of urine samples in two Italian isolated populations
|
|---|---|
| Published in |
Amino Acids, December 2008
|
| DOI | 10.1007/s00726-008-0205-8 |
| Pubmed ID | |
| Authors |
Pio D’Adamo, Sheila Ulivi, Amerigo Beneduci, Gabriele Pontoni, Giovambattista Capasso, Carmela Lanzara, Gilberto Andrighetto, Uros Hladnik, Virginia Nunes, Manuel Palacin, Paolo Gasparini |
| Abstract |
The study of two different Italian isolated populations was combined with a metabonomic approach to better understand tubular handling of amino acids. Levels of amino acids and metabolites have been analyzed by Nucleic Magnetic Resonance and expressed as ratio vs urinary creatinine concentration (mmol/mol). For most of the amino acids there is an age-related U shape pattern of excretion, with the peaks during childhood and old age, and a significant reduction in the adult age. Hierarchical cluster analysis has clearly identified three groups clustering the same amino acids: His, Thr and Ala (group one); Gly and Phe (group two) and a third larger one. Results have been further confirmed by factor and regression analysis, and used to confirm and, in some cases, infer new amino acids networks. As a matter of facts, the identification of strong evidences for clustering of urine excretion of several neutral amino acids suggests the predominant impact of relevant and common transporters. |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Malaysia | 1 | 3% |
| United Kingdom | 1 | 3% |
| Italy | 1 | 3% |
| Brazil | 1 | 3% |
| Unknown | 26 | 87% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 37% |
| Student > Ph. D. Student | 5 | 17% |
| Professor > Associate Professor | 4 | 13% |
| Student > Master | 2 | 7% |
| Student > Bachelor | 1 | 3% |
| Other | 5 | 17% |
| Unknown | 2 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 27% |
| Agricultural and Biological Sciences | 8 | 27% |
| Chemistry | 4 | 13% |
| Environmental Science | 2 | 7% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Other | 1 | 3% |
| Unknown | 5 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2016.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Amino Acids
#495
of 1,518 outputs
Outputs of similar age
#47,561
of 165,353 outputs
Outputs of similar age from Amino Acids
#5
of 9 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,518 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
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We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.