Title |
Catheter-based renal sympathetic denervation: chronic preclinical evidence for renal artery safety
|
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Published in |
Clinical Research in Cardiology, July 2011
|
DOI | 10.1007/s00392-011-0346-8 |
Pubmed ID | |
Authors |
Marian K. Rippy, Denise Zarins, Neil C. Barman, Andrew Wu, Keith L. Duncan, Christopher K. Zarins |
Abstract |
Renal sympathetic hyperactivity is associated with hypertension, a leading cause of mortality worldwide. Renal sympathetic denervation via the Symplicity Catheter System has been shown to decrease blood pressure by 33/11 mmHg by 6 months, with no radiofrequency (RF)-related adverse sequelae visible by CT/MR angiography or renal duplex ultrasound 6 months after the procedure. Here, we present preclinical work predating those clinical results. We performed therapeutic renal sympathetic denervation in a swine animal model to characterize the vascular safety and healing response 6 months after renal denervation therapy. |
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