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Mutated G4P[8] Rotavirus Associated with a Nationwide Outbreak of Gastroenteritis in Nicaragua in 2005▿

Overview of attention for article published in Journal of Clinical Microbiology, January 2007
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

Mentioned by

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1 policy source
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15 Wikipedia pages

Citations

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48 Dimensions

Readers on

mendeley
37 Mendeley
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Title
Mutated G4P[8] Rotavirus Associated with a Nationwide Outbreak of Gastroenteritis in Nicaragua in 2005▿
Published in
Journal of Clinical Microbiology, January 2007
DOI 10.1128/jcm.01992-06
Pubmed ID
Authors

Filemon Bucardo, Beatrice Karlsson, Johan Nordgren, Margarita Paniagua, Alcides González, Juan Jose Amador, Felix Espinoza, Lennart Svensson

Abstract

During February and March 2005, one of the largest national recorded outbreaks of severe acute gastroenteritis occurred in Nicaragua, affecting >or=64,000 individuals and causing >or=56 deaths, predominantly in children under 5 years of age. Through a nationwide laboratory-based study, stool samples were collected and investigated for rotavirus. Of 108 stool samples examined, 72 (67%) were positive for rotavirus. While 69% (50/72) of the positive samples were found in children less than 2 years of age, 50% (6/12) of the adult samples were positive. A mutated G4P[8] strain was the most commonly recognized strain (85%), followed by mixed G strains (8%) and G9P[8] (7%) strains. Phylogenetic analysis of the VP7 gene revealed that the G4 strains belonged to the emerging lineage Ic and was distantly related to the ST3 and VA70 G4 strains. Secondary structure predictions of the VP7 G4 protein revealed an insert of an asparagine residue in position 76, which, combined with additional mutations, surprisingly modified two downstream beta-sheets at amino acid positions 80 to 85 and 115 to 119. The 2005 G4P[8] strain compared to a G4P[8] strain from 2002 had a substitution of an asparagine residue for threonine (Asn-->Thr) at position 96 within antigenic region A, thus eliminating a potential glycosylation site. The mutated G4 virus was introduced in Nicaragua after 2002 and probably emerged from Brazil, Argentina, or Uruguay.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Uzbekistan 1 3%
Argentina 1 3%
Unknown 35 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 22%
Student > Bachelor 7 19%
Researcher 5 14%
Student > Doctoral Student 2 5%
Student > Ph. D. Student 2 5%
Other 4 11%
Unknown 9 24%
Readers by discipline Count As %
Medicine and Dentistry 9 24%
Agricultural and Biological Sciences 8 22%
Biochemistry, Genetics and Molecular Biology 4 11%
Immunology and Microbiology 3 8%
Computer Science 1 3%
Other 2 5%
Unknown 10 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2024.
All research outputs
#5,447,195
of 25,374,917 outputs
Outputs from Journal of Clinical Microbiology
#3,325
of 14,318 outputs
Outputs of similar age
#23,851
of 173,046 outputs
Outputs of similar age from Journal of Clinical Microbiology
#16
of 74 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,318 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,046 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.