| Title |
The proto-oncogene C-KIT maps to canid B-chromosomes
|
|---|---|
| Published in |
Chromosome Research, February 2005
|
| DOI | 10.1007/s10577-005-7474-9 |
| Pubmed ID | |
| Authors |
Alexander S. Graphodatsky, Anna V. Kukekova, Dmitry V. Yudkin, Vladimir A. Trifonov, Nadezhda V. Vorobieva, Violetta R. Beklemisheva, Polina L. Perelman, Daria A. Graphodatskaya, Lyudmila N. Trut, Fengtang Yang, Malcolm A. Ferguson-Smith, Gregory M. Acland, Gustavo D. Aguirre |
| Abstract |
Plant and animal karyotypes sometimes contain variable elements, that are referred to as additional or B-chromosomes. It is generally believed that B-chromosomes lack major genes and represent parasitic and selfish elements of a genome. Here we report, for the first time, the localization of a gene to B-chromosomes of mammals: red fox (Vulpes vulpes) and two subspecies of raccoon dog (Nyctereutes procyonoides). Identification of the proto-oncogene C-KIT on B-chromosomes of two Canidae species that diverged from a common ancestor more than 12.5 million years ago argues against the current view of B-chromosomes. Analyses of fox B-chromosomal C-KIT gene from a flow-sorted fox B-chromosome-specific library revealed the presence of intron-exon boundaries and high identity between sequenced regions of canine and fox B-chromosomal C-KIT copies. Identification of C-KIT gene on all B-chromosomes of two canid species provides new insight into the origin and evolution of supernumeraries and their potential role in the genome. |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 4% |
| United Kingdom | 1 | 2% |
| Unknown | 52 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 16% |
| Student > Ph. D. Student | 7 | 13% |
| Student > Bachelor | 7 | 13% |
| Student > Postgraduate | 6 | 11% |
| Student > Doctoral Student | 4 | 7% |
| Other | 13 | 24% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 51% |
| Biochemistry, Genetics and Molecular Biology | 11 | 20% |
| Veterinary Science and Veterinary Medicine | 1 | 2% |
| Linguistics | 1 | 2% |
| Environmental Science | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 11 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2016.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Chromosome Research
#145
of 507 outputs
Outputs of similar age
#36,531
of 141,301 outputs
Outputs of similar age from Chromosome Research
#3
of 7 outputs
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