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Mendeley readers
Attention Score in Context
| Title |
Direct conversion of fibroblasts into neural progenitor-like cells by forced growth into 3D spheres on low attachment surfaces
|
|---|---|
| Published in |
Clinical Materials, May 2013
|
| DOI | 10.1016/j.biomaterials.2013.04.040 |
| Pubmed ID | |
| Authors |
Guannan Su, Yannan Zhao, Jianshu Wei, Zhifeng Xiao, Bing Chen, Jin Han, Lei Chen, Jian Guan, Renzhi Wang, Qun Dong, Jianwu Dai |
| Abstract |
Many stem cells grow into three-dimensional (3D) spheres or colonies, such as neural progenitor cells (NPCs) and embryonic stem cells (ESCs). Sphere morphology helps maintaining the stemness of stem cells. Our previous study demonstrated that forced growth of RT4 and HEK293 cells into 3D sphere on low attachment surface could induce stem cell properties. The close relationship between 3D sphere morphology and stem cell stemness drives us to hypothesize that 3D sphere formation induces fibroblasts reprogramming. The key gene Sox2 for reprogramming fibroblasts into NPCs was found to be overexpressed in 3D sphere cultured mouse fibroblasts. These cells exhibited similar morphological and molecular features to NPCs in vitro, were capable of differentiating into neurons, astrocytes and oligodendrocytes, and could generate long-term expandable neurospheres while maintaining differentiation capability. When engrafted into hippocampus of adult rat brain, the 3D sphere cells differentiated into neural cells. Thus, NPCs can be generated from fibroblasts directly through a physical approach without introducing exogenous reprogramming factors. |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 79 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 23% |
| Researcher | 17 | 21% |
| Professor > Associate Professor | 9 | 11% |
| Student > Master | 8 | 10% |
| Student > Bachelor | 6 | 7% |
| Other | 12 | 15% |
| Unknown | 10 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 38% |
| Engineering | 9 | 11% |
| Neuroscience | 8 | 10% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Medicine and Dentistry | 6 | 7% |
| Other | 7 | 9% |
| Unknown | 13 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2022.
All research outputs
#3,798,945
of 25,374,917 outputs
Outputs from Clinical Materials
#1,161
of 10,751 outputs
Outputs of similar age
#31,372
of 204,978 outputs
Outputs of similar age from Clinical Materials
#16
of 126 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,751 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 204,978 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.