| Title |
Epigenetic mechanisms underlying extinction of memory and drug-seeking behavior
|
|---|---|
| Published in |
Mammalian Genome, September 2009
|
| DOI | 10.1007/s00335-009-9224-3 |
| Pubmed ID | |
| Authors |
Melissa Malvaez, Ruth M. Barrett, Marcelo A. Wood, Carles Sanchis-Segura |
| Abstract |
An increasing body of evidence shows that structural modifications of chromatin, the DNA-protein complex that packages genomic DNA, do not only participate in maintaining cellular memory (e.g., cell fate), but they may also underlie the strengthening and maintenance of synaptic connections required for long-term changes in behavior. Accordingly, epigenetics has become a central topic in several neurobiology fields such as memory, drug addiction, and several psychiatric and mental disorders. This interest is justified as dynamic chromatin modifications may provide not only transient but also stable (or even potentially permanent) epigenetic marks to facilitate, maintain, or block transcriptional processes, which in turn may participate in the molecular neural adaptations underlying behavioral changes. Through epigenetic mechanisms the genome may be indexed in response to environmental signals, resulting in specific neural modifications that largely determine the future behavior of an organism. In this review we discuss recent advances in our understanding of how epigenetic mechanisms contribute to the formation of long-term memory and drug-seeking behavior and potentially how to apply that knowledge to the extinction of memory and drug-seeking behavior. |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| Switzerland | 1 | 1% |
| Italy | 1 | 1% |
| Australia | 1 | 1% |
| Germany | 1 | 1% |
| Canada | 1 | 1% |
| United Kingdom | 1 | 1% |
| Greece | 1 | 1% |
| Spain | 1 | 1% |
| Other | 0 | 0% |
| Unknown | 65 | 86% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 22% |
| Researcher | 17 | 22% |
| Professor | 9 | 12% |
| Student > Master | 7 | 9% |
| Student > Bachelor | 6 | 8% |
| Other | 14 | 18% |
| Unknown | 6 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 38% |
| Psychology | 14 | 18% |
| Neuroscience | 9 | 12% |
| Medicine and Dentistry | 8 | 11% |
| Nursing and Health Professions | 1 | 1% |
| Other | 6 | 8% |
| Unknown | 9 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2021.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Mammalian Genome
#318
of 1,126 outputs
Outputs of similar age
#33,061
of 92,957 outputs
Outputs of similar age from Mammalian Genome
#1
of 4 outputs
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