| Title |
The small RNA Aar in Acinetobacter baylyi: a putative regulator of amino acid metabolism
|
|---|---|
| Published in |
Archives of Microbiology, June 2010
|
| DOI | 10.1007/s00203-010-0592-6 |
| Pubmed ID | |
| Authors |
Dominik Schilling, Sven Findeiß, Andreas S. Richter, Jennifer A. Taylor, Ulrike Gerischer |
| Abstract |
Small non-coding RNAs (sRNAs) are key players in prokaryotic metabolic circuits, allowing the cell to adapt to changing environmental conditions. Regulatory interference by sRNAs in cellular metabolism is often facilitated by the Sm-like protein Hfq. A search for novel sRNAs in A. baylyi intergenic regions was performed by a biocomputational screening. One candidate, Aar, encoded between trpS and sucD showed Hfq dependency in Northern blot analysis. Aar was expressed strongly during stationary growth phase in minimal medium; in contrast, in complex medium, strongest expression was in the exponential growth phase. Whereas over-expression of Aar in trans did not affect bacterial growth, seven mRNA targets predicted by two in silico approaches were upregulated in stationary growth phase. All seven mRNAs are involved in A. baylyi amino acid metabolism. A putative binding site for Lrp, the global regulator of branched-chain amino acids in E. coli, was observed within the aar gene. Both facts imply an Aar participation in amino acid metabolism. |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | 3% |
| India | 1 | 3% |
| Unknown | 27 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 28% |
| Student > Ph. D. Student | 8 | 28% |
| Student > Master | 6 | 21% |
| Professor | 2 | 7% |
| Student > Doctoral Student | 1 | 3% |
| Other | 2 | 7% |
| Unknown | 2 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 38% |
| Biochemistry, Genetics and Molecular Biology | 5 | 17% |
| Immunology and Microbiology | 5 | 17% |
| Medicine and Dentistry | 2 | 7% |
| Computer Science | 2 | 7% |
| Other | 2 | 7% |
| Unknown | 2 | 7% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2012.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Archives of Microbiology
#568
of 2,770 outputs
Outputs of similar age
#33,451
of 94,008 outputs
Outputs of similar age from Archives of Microbiology
#1
of 4 outputs
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