| Title |
Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging
|
|---|---|
| Published in |
Biogerontology, December 2008
|
| DOI | 10.1007/s10522-008-9205-z |
| Pubmed ID | |
| Authors |
Dharmendra Kumar Singh, Byungchan Ahn, Vilhelm A. Bohr |
| Abstract |
The maintenance of the stability of genetic material is an essential feature of every living organism. Organisms across all kingdoms have evolved diverse and highly efficient repair mechanisms to protect the genome from deleterious consequences of various genotoxic factors that might tend to destabilize the integrity of the genome in each generation. One such group of proteins that is actively involved in genome surveillance is the RecQ helicase family. These proteins are highly conserved DNA helicases, which have diverse roles in multiple DNA metabolic processes such as DNA replication, recombination and DNA repair. In humans, five RecQ helicases have been identified and three of them namely, WRN, BLM and RecQL4 have been linked to genetic diseases characterized by genome instability, premature aging and cancer predisposition. This helicase family plays important roles in various DNA repair pathways including protecting the genome from illegitimate recombination during chromosome segregation in mitosis and assuring genome stability. This review mainly focuses on various roles of human RecQ helicases in the process of recombination-based DNA repair to maintain genome stability and physiological consequences of their defects in the development of cancer and premature aging. |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 2% |
| United States | 2 | 2% |
| France | 1 | 1% |
| Canada | 1 | 1% |
| United Kingdom | 1 | 1% |
| Japan | 1 | 1% |
| Spain | 1 | 1% |
| Unknown | 73 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 39% |
| Researcher | 14 | 17% |
| Student > Master | 8 | 10% |
| Student > Bachelor | 6 | 7% |
| Professor > Associate Professor | 5 | 6% |
| Other | 9 | 11% |
| Unknown | 8 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 43 | 52% |
| Biochemistry, Genetics and Molecular Biology | 18 | 22% |
| Medicine and Dentistry | 6 | 7% |
| Chemistry | 3 | 4% |
| Arts and Humanities | 2 | 2% |
| Other | 3 | 4% |
| Unknown | 7 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2019.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Biogerontology
#276
of 646 outputs
Outputs of similar age
#48,225
of 167,183 outputs
Outputs of similar age from Biogerontology
#6
of 8 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 646 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
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We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.