Title |
Adhesion, migration and communication in melanocytes and melanoma
|
---|---|
Published in |
Pigment Cell & Melanoma Research, May 2005
|
DOI | 10.1111/j.1600-0749.2005.00235.x |
Pubmed ID | |
Authors |
Nikolas K. Haass, Keiran S. M. Smalley, Ling Li, Meenhard Herlyn |
Abstract |
Under normal conditions, homeostasis determines whether a cell remains quiescent, proliferates, differentiates, or undergoes apoptosis. In this state of homeostasis, keratinocytes control melanocyte growth and behaviour through a complex system of paracrine growth factors and cell-cell adhesion molecules. Alteration of this delicate homeostatic balance and can lead to altered expression of cell-cell adhesion and cell communication molecules and to the development of melanoma. Melanoma cells escape from this control by keratinocytes through three major mechanisms: (1) down-regulation of receptors important for communication with keratinocytes such as E-cadherin, P-cadherin, desmoglein and connexins, which is achieved through growth factors produced by fibroblasts or keratinocytes; (2) up-regulation of receptors and signalling molecules not found on melanocytes but important for melanoma-melanoma and melanoma-fibroblast interactions such as N-cadherin, Mel-CAM, and zonula occludens protein-1 (ZO-1); (3) loss of anchorage to the basement membrane because of an altered expression of the extracellular-matrix binding integrin family. In the current review, we describe the alterations in cell-cell adhesion and communication associated with melanoma development and progression, and discuss how a greater understanding of these processes may aid the future therapy of this disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | <1% |
Brazil | 2 | <1% |
Portugal | 1 | <1% |
Netherlands | 1 | <1% |
South Africa | 1 | <1% |
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
Sri Lanka | 1 | <1% |
Denmark | 1 | <1% |
Other | 3 | 1% |
Unknown | 280 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 65 | 22% |
Researcher | 47 | 16% |
Student > Bachelor | 44 | 15% |
Student > Master | 41 | 14% |
Professor > Associate Professor | 14 | 5% |
Other | 39 | 13% |
Unknown | 44 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 92 | 31% |
Biochemistry, Genetics and Molecular Biology | 75 | 26% |
Medicine and Dentistry | 35 | 12% |
Immunology and Microbiology | 9 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 2% |
Other | 24 | 8% |
Unknown | 53 | 18% |