| Title |
Endogenous retroviruses
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, September 2008
|
| DOI | 10.1007/s00018-008-8500-9 |
| Pubmed ID | |
| Authors |
F. Arnaud, M. Varela, T. E. Spencer, M. Palmarini |
| Abstract |
Sheep betaretroviruses offer a unique model system to study the complex interaction between retroviruses and their host. Jaagsiekte sheep retrovirus (JSRV) is a pathogenic exogenous retrovirus and the causative agent of ovine pulmonary adenocarcinoma. The sheep genome contains at least 27 copies of endogenous retroviruses (enJSRVs) highly related to JSRV. enJSRVs have played several roles in the evolution of the domestic sheep as they are able to block the JSRV replication cycle and play a critical role in sheep conceptus development and placental morphogenesis. Available data strongly suggest that some dominant negative enJSRV proviruses (i.e. able to block JSRV replication) have been positively selected during evolution. Interestingly, viruses escaping the transdominant enJSRV loci have recently emerged (less than 200 years ago). Thus, endogenization of these retroviruses may still be occurring today. Therefore, sheep provide an exciting and unique system to study retrovirus-host coevolution. (Part of a multi-author review). |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 3% |
| Spain | 2 | 3% |
| Chile | 1 | 1% |
| United Kingdom | 1 | 1% |
| Brazil | 1 | 1% |
| South Africa | 1 | 1% |
| Egypt | 1 | 1% |
| Unknown | 61 | 87% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 31% |
| Student > Ph. D. Student | 17 | 24% |
| Student > Bachelor | 4 | 6% |
| Student > Doctoral Student | 3 | 4% |
| Professor | 3 | 4% |
| Other | 12 | 17% |
| Unknown | 9 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 36 | 51% |
| Biochemistry, Genetics and Molecular Biology | 9 | 13% |
| Medicine and Dentistry | 6 | 9% |
| Immunology and Microbiology | 3 | 4% |
| Veterinary Science and Veterinary Medicine | 2 | 3% |
| Other | 3 | 4% |
| Unknown | 11 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 57. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2022.
All research outputs
#667,028
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#47
of 4,151 outputs
Outputs of similar age
#1,321
of 90,042 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#1
of 47 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 90,042 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.