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Dcytb (Cybrd1) functions as both a ferric and a cupric reductase in vitro

Overview of attention for article published in Febs Letters, May 2008
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Title
Dcytb (Cybrd1) functions as both a ferric and a cupric reductase in vitro
Published in
Febs Letters, May 2008
DOI 10.1016/j.febslet.2008.05.010
Pubmed ID
Authors

Steven Wyman, Robert J. Simpson, Andrew T. McKie, Paul A. Sharp

Abstract

MDCK cells expressing an inducible duodenal cytochrome b-green fluorescent protein (Dcytb-EGFP) fusion construct were used to investigate the function of Dcytb. The Dcytb-EGFP protein was targeted correctly to the plasma membrane, and cells displayed increased ferric and cupric reductase activities, which were greatly reduced in the presence of doxycycline. The data suggests that Dcytb plays a physiological role in both iron and copper uptake, through divalent metal transporter 1 (DMT1) and copper transporter 1, respectively. In support of this hypothesis, we show that 59Fe uptake was significantly enhanced in Dcytb-EGFP expressing MDCK cells which endogenously express DMT1.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Italy 1 2%
Unknown 60 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 29%
Student > Ph. D. Student 11 17%
Student > Bachelor 7 11%
Student > Doctoral Student 4 6%
Student > Master 4 6%
Other 9 14%
Unknown 10 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 32%
Agricultural and Biological Sciences 17 27%
Chemistry 4 6%
Engineering 3 5%
Environmental Science 2 3%
Other 6 10%
Unknown 11 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2015.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Febs Letters
#4,917
of 14,373 outputs
Outputs of similar age
#33,530
of 96,544 outputs
Outputs of similar age from Febs Letters
#18
of 43 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,373 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,544 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.