| Title |
The Fanconi anemia pathway and DNA interstrand cross-link repair
|
|---|---|
| Published in |
Protein & Cell, September 2011
|
| DOI | 10.1007/s13238-011-1098-y |
| Pubmed ID | |
| Authors |
Xiaoyu Su, Jun Huang |
| Abstract |
Fanconi anemia (FA) is an autosomal or X-linked recessive disorder characterized by chromosomal instability, bone marrow failure, cancer susceptibility, and a profound sensitivity to agents that produce DNA interstrand cross-link (ICL). To date, 15 genes have been identified that, when mutated, result in FA or an FA-like syndrome. It is believed that cellular resistance to DNA interstrand cross-linking agents requires all 15 FA or FA-like proteins. Here, we review our current understanding of how these FA proteins participate in ICL repair and discuss the molecular mechanisms that regulate the FA pathway to maintain genome stability. |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 3% |
| Denmark | 2 | 3% |
| Netherlands | 1 | 1% |
| Austria | 1 | 1% |
| Unknown | 74 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 28% |
| Researcher | 14 | 18% |
| Student > Bachelor | 11 | 14% |
| Student > Master | 11 | 14% |
| Professor | 4 | 5% |
| Other | 8 | 10% |
| Unknown | 10 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 41% |
| Biochemistry, Genetics and Molecular Biology | 20 | 25% |
| Chemistry | 5 | 6% |
| Medicine and Dentistry | 4 | 5% |
| Nursing and Health Professions | 2 | 3% |
| Other | 4 | 5% |
| Unknown | 12 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2017.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Protein & Cell
#284
of 738 outputs
Outputs of similar age
#44,630
of 130,826 outputs
Outputs of similar age from Protein & Cell
#3
of 9 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 738 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,826 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.